FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2419189905> ?p ?o ?g. }

• W2419189905 endingPage "759" @default.
• W2419189905 startingPage "754" @default.
• W2419189905 abstract "Objective To study the biological impact and mechanism of recombinant tissue factor pathway inhibitor (rTFPI) on apoptosis of rat kidney mesangial cells (MsC). Methods TFPI expression in human glomerular minor lesion (GML), mesangial proliferative glomerulonephritis (MPGN) and cultured rat MsC was detected using immunohistochemistry and immunofluorescence, respectively. Rat MsC were incubated with rTFPI and its variant peptides. Morphological changes of apoptosis were investigated by Hoechst 33258 and the apoptotic rate was assessed by flow cytometry. DNA fragmentation and effect of rTFPI on expression of caspase-3, Fas and bcl-2 were studied using gel electrophoresis and Western blot respectively. Results The expression of TFPI in MPGN was higher than that in GML. TFPI was expressed in cultured rat mesangial cells. Apoptosis of MsC was induced by rTFPI, especially by its C-termianl, in a dose- and time-dependent manner. Apoptosis ratios of MsC treated with rTFPI were 2.1,3.0 and 4.9 times more than control, respectively. Expression of gene caspase-3 and Fas was up-regulated in a dose-dependent manner wherease bcl-2 expression did not show any changes. Conclusion rTFPI induces apoptosis in cultured rat mesangial cells by its C-terminal possibly via Fas/FasL pathway.Key words: Mesangial cells;  Apoptosis;  Antigens,CD95 ;  Rat" @default.
• W2419189905 created "2016-06-24" @default.
• W2419189905 creator A5013676552 @default.
• W2419189905 creator A5019610452 @default.
• W2419189905 creator A5033199845 @default.
• W2419189905 creator A5052590910 @default.
• W2419189905 creator A5053003412 @default.
• W2419189905 creator A5075733288 @default.
• W2419189905 date "2008-11-01" @default.
• W2419189905 modified "2023-09-22" @default.
• W2419189905 title "[Effect of tissue factor pathway inhibitor on apoptosis of rat mesangial cells and Fas and bcl-2 expression]." @default.
• W2419189905 doi "https://doi.org/10.3321/j.issn:0529-5807.2008.11.007" @default.
• W2419189905 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19094710" @default.
• W2419189905 hasPublicationYear "2008" @default.
• W2419189905 type Work @default.
• W2419189905 sameAs 2419189905 @default.
• W2419189905 citedByCount "0" @default.
• W2419189905 crossrefType "journal-article" @default.
• W2419189905 hasAuthorship W2419189905A5013676552 @default.
• W2419189905 hasAuthorship W2419189905A5019610452 @default.
• W2419189905 hasAuthorship W2419189905A5033199845 @default.
• W2419189905 hasAuthorship W2419189905A5052590910 @default.
• W2419189905 hasAuthorship W2419189905A5053003412 @default.
• W2419189905 hasAuthorship W2419189905A5075733288 @default.
• W2419189905 hasConcept C104317684 @default.
• W2419189905 hasConcept C126322002 @default.
• W2419189905 hasConcept C134018914 @default.
• W2419189905 hasConcept C153911025 @default.
• W2419189905 hasConcept C159654299 @default.
• W2419189905 hasConcept C185592680 @default.
• W2419189905 hasConcept C186738567 @default.
• W2419189905 hasConcept C190283241 @default.
• W2419189905 hasConcept C203014093 @default.
• W2419189905 hasConcept C2776415932 @default.
• W2419189905 hasConcept C2777151630 @default.
• W2419189905 hasConcept C2778236600 @default.
• W2419189905 hasConcept C2778382381 @default.
• W2419189905 hasConcept C2779131090 @default.
• W2419189905 hasConcept C2780091579 @default.
• W2419189905 hasConcept C2780368995 @default.
• W2419189905 hasConcept C2780688133 @default.
• W2419189905 hasConcept C3031857 @default.
• W2419189905 hasConcept C31573885 @default.
• W2419189905 hasConcept C40767141 @default.
• W2419189905 hasConcept C43759708 @default.
• W2419189905 hasConcept C553184892 @default.
• W2419189905 hasConcept C55493867 @default.
• W2419189905 hasConcept C66008609 @default.
• W2419189905 hasConcept C71924100 @default.
• W2419189905 hasConcept C86803240 @default.
• W2419189905 hasConceptScore W2419189905C104317684 @default.
• W2419189905 hasConceptScore W2419189905C126322002 @default.
• W2419189905 hasConceptScore W2419189905C134018914 @default.
• W2419189905 hasConceptScore W2419189905C153911025 @default.
• W2419189905 hasConceptScore W2419189905C159654299 @default.
• W2419189905 hasConceptScore W2419189905C185592680 @default.
• W2419189905 hasConceptScore W2419189905C186738567 @default.
• W2419189905 hasConceptScore W2419189905C190283241 @default.
• W2419189905 hasConceptScore W2419189905C203014093 @default.
• W2419189905 hasConceptScore W2419189905C2776415932 @default.
• W2419189905 hasConceptScore W2419189905C2777151630 @default.
• W2419189905 hasConceptScore W2419189905C2778236600 @default.
• W2419189905 hasConceptScore W2419189905C2778382381 @default.
• W2419189905 hasConceptScore W2419189905C2779131090 @default.
• W2419189905 hasConceptScore W2419189905C2780091579 @default.
• W2419189905 hasConceptScore W2419189905C2780368995 @default.
• W2419189905 hasConceptScore W2419189905C2780688133 @default.
• W2419189905 hasConceptScore W2419189905C3031857 @default.
• W2419189905 hasConceptScore W2419189905C31573885 @default.
• W2419189905 hasConceptScore W2419189905C40767141 @default.
• W2419189905 hasConceptScore W2419189905C43759708 @default.
• W2419189905 hasConceptScore W2419189905C553184892 @default.
• W2419189905 hasConceptScore W2419189905C55493867 @default.
• W2419189905 hasConceptScore W2419189905C66008609 @default.
• W2419189905 hasConceptScore W2419189905C71924100 @default.
• W2419189905 hasConceptScore W2419189905C86803240 @default.
• W2419189905 hasIssue "11" @default.
• W2419189905 hasLocation W24191899051 @default.
• W2419189905 hasLocation W24191899052 @default.
• W2419189905 hasOpenAccess W2419189905 @default.
• W2419189905 hasPrimaryLocation W24191899051 @default.
• W2419189905 hasRelatedWork W1985132240 @default.
• W2419189905 hasRelatedWork W1986352756 @default.
• W2419189905 hasRelatedWork W2001643188 @default.
• W2419189905 hasRelatedWork W2010658002 @default.
• W2419189905 hasRelatedWork W2011924373 @default.
• W2419189905 hasRelatedWork W2028421260 @default.
• W2419189905 hasRelatedWork W2031950207 @default.
• W2419189905 hasRelatedWork W2037123678 @default.
• W2419189905 hasRelatedWork W2079398575 @default.
• W2419189905 hasRelatedWork W2094375438 @default.
• W2419189905 hasRelatedWork W2112578757 @default.
• W2419189905 hasRelatedWork W2355594559 @default.
• W2419189905 hasRelatedWork W2363926990 @default.
• W2419189905 hasRelatedWork W2374184093 @default.
• W2419189905 hasRelatedWork W2374443629 @default.
• W2419189905 hasRelatedWork W2377159784 @default.
• W2419189905 hasRelatedWork W2385690705 @default.

• next