FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2419215047> ?p ?o ?g. }

• W2419215047 startingPage "124" @default.
• W2419215047 abstract "The pathophysiological process of natural human aging has not been studied adequately due to the lack of an appropriate human model. Since recent investigations have suggested that possibly contributes to the pathogenesis of age-related disorders including atherosclerosis, cancer, and diabetes mellitus, the term inflammaging, a combination of inflammation and has been coined. Werner syndrome (WS), caused by the loss of function of RecQ3 DNA/RNA helicase, is a typical progeroid syndrome mimicking natural aging, although it is extremely rare outside of Japan. We sought to examine WS patients from an immunological/inflammatory perspective. Sera from 14 mutation-proven WS patients (ages: 33-70 years) and 21 healthy Japanese adults ages 15 to 95 years were examined with ELISA for soluble Fas ligand (sFasL) to compare conventional markers. With natural aging, a statistically significant correlation (p < 0.0001) was observed in the serum level of sFasL. The sFasL in WS, a level comparable to that in healthy elderly ages 83 to 95 years, had significantly increased (p < 0.05) compared to that in young healthy individuals ages 15 to 70 years. A significant correlation was noted between the serum levels of conventional markers such as CRP (p < 0.025), ESR (p < 0.024), and WBC count (p < 0.0085). In conclusion, an increased level of serum sFasL in natural aging and WS patients may suggest a common pathophysiological mechanism: inflammation. WS may be a good model for analyzing inflammaging." @default.
• W2419215047 created "2016-06-24" @default.
• W2419215047 creator A5091648023 @default.
• W2419215047 date "2008-06-01" @default.
• W2419215047 modified "2023-09-23" @default.
• W2419215047 title "Elevation of soluble Fas (APO-1, CD95) ligand in natural aging and Werner syndrome." @default.
• W2419215047 cites W1517945724 @default.
• W2419215047 cites W1571529930 @default.
• W2419215047 cites W157680310 @default.
• W2419215047 cites W1656708631 @default.
• W2419215047 cites W1965037168 @default.
• W2419215047 cites W1967531243 @default.
• W2419215047 cites W1968460725 @default.
• W2419215047 cites W1975336660 @default.
• W2419215047 cites W1979664563 @default.
• W2419215047 cites W1987808828 @default.
• W2419215047 cites W2002415495 @default.
• W2419215047 cites W2002503549 @default.
• W2419215047 cites W2003231014 @default.
• W2419215047 cites W2006527080 @default.
• W2419215047 cites W2015871681 @default.
• W2419215047 cites W2038230962 @default.
• W2419215047 cites W2051633109 @default.
• W2419215047 cites W2052853635 @default.
• W2419215047 cites W2059848377 @default.
• W2419215047 cites W2064074285 @default.
• W2419215047 cites W2065784864 @default.
• W2419215047 cites W2067096368 @default.
• W2419215047 cites W2067419827 @default.
• W2419215047 cites W2078902750 @default.
• W2419215047 cites W2079430799 @default.
• W2419215047 cites W2095000492 @default.
• W2419215047 cites W2109330502 @default.
• W2419215047 cites W2110062670 @default.
• W2419215047 cites W2118917377 @default.
• W2419215047 cites W2138955470 @default.
• W2419215047 cites W2155835896 @default.
• W2419215047 cites W2166522497 @default.
• W2419215047 cites W2232248512 @default.
• W2419215047 cites W2265871020 @default.
• W2419215047 cites W2313222791 @default.
• W2419215047 cites W2405236315 @default.
• W2419215047 cites W2417293982 @default.
• W2419215047 cites W55582296 @default.
• W2419215047 cites W1999434336 @default.
• W2419215047 cites W2461361167 @default.
• W2419215047 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20103915" @default.
• W2419215047 hasPublicationYear "2008" @default.
• W2419215047 type Work @default.
• W2419215047 sameAs 2419215047 @default.
• W2419215047 citedByCount "5" @default.
• W2419215047 countsByYear W24192150472017 @default.
• W2419215047 countsByYear W24192150472018 @default.
• W2419215047 countsByYear W24192150472022 @default.
• W2419215047 crossrefType "journal-article" @default.
• W2419215047 hasAuthorship W2419215047A5091648023 @default.
• W2419215047 hasConcept C10162356 @default.
• W2419215047 hasConcept C104317684 @default.
• W2419215047 hasConcept C121608353 @default.
• W2419215047 hasConcept C126322002 @default.
• W2419215047 hasConcept C134018914 @default.
• W2419215047 hasConcept C161223559 @default.
• W2419215047 hasConcept C163276114 @default.
• W2419215047 hasConcept C190283241 @default.
• W2419215047 hasConcept C203014093 @default.
• W2419215047 hasConcept C2776914184 @default.
• W2419215047 hasConcept C2778090637 @default.
• W2419215047 hasConcept C2780942790 @default.
• W2419215047 hasConcept C2909947164 @default.
• W2419215047 hasConcept C31573885 @default.
• W2419215047 hasConcept C42407357 @default.
• W2419215047 hasConcept C522857546 @default.
• W2419215047 hasConcept C54355233 @default.
• W2419215047 hasConcept C555293320 @default.
• W2419215047 hasConcept C66008609 @default.
• W2419215047 hasConcept C67705224 @default.
• W2419215047 hasConcept C71924100 @default.
• W2419215047 hasConcept C86803240 @default.
• W2419215047 hasConceptScore W2419215047C10162356 @default.
• W2419215047 hasConceptScore W2419215047C104317684 @default.
• W2419215047 hasConceptScore W2419215047C121608353 @default.
• W2419215047 hasConceptScore W2419215047C126322002 @default.
• W2419215047 hasConceptScore W2419215047C134018914 @default.
• W2419215047 hasConceptScore W2419215047C161223559 @default.
• W2419215047 hasConceptScore W2419215047C163276114 @default.
• W2419215047 hasConceptScore W2419215047C190283241 @default.
• W2419215047 hasConceptScore W2419215047C203014093 @default.
• W2419215047 hasConceptScore W2419215047C2776914184 @default.
• W2419215047 hasConceptScore W2419215047C2778090637 @default.
• W2419215047 hasConceptScore W2419215047C2780942790 @default.
• W2419215047 hasConceptScore W2419215047C2909947164 @default.
• W2419215047 hasConceptScore W2419215047C31573885 @default.
• W2419215047 hasConceptScore W2419215047C42407357 @default.
• W2419215047 hasConceptScore W2419215047C522857546 @default.
• W2419215047 hasConceptScore W2419215047C54355233 @default.
• W2419215047 hasConceptScore W2419215047C555293320 @default.
• W2419215047 hasConceptScore W2419215047C66008609 @default.
• W2419215047 hasConceptScore W2419215047C67705224 @default.
• W2419215047 hasConceptScore W2419215047C71924100 @default.

• next