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- W2419233152 abstract "AIM To perform a comparison of genetic characteristics of vaccine strain EV and its putative derivatives, obtained after passages through highly susceptible animals, in order to identify the strains-revertants and establish their possible origin. MATERIALS AND METHODS Yersinia pestis EV strains and its putative were used in the study. Polymerase chain reaction and DNA-DNA hybridization were used for genetic analysis. RESULTS Comparison of several genetic characteristics of vaccine strain EV and its putative allowed to establish that virulent revertants are not derivatives of vaccine strain EV because they do not belong to East biovar, do not have ribotype characteristic for EV strain and contain pigmentation area, which is absent in vaccine strain. CONCLUSION Obtained results evidence against possibility of reversion of vaccine EV strain to virulent forms in organisms of highly susceptible animals and confirm its safety for vaccination." @default.
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- W2419233152 date "2009-05-01" @default.
- W2419233152 modified "2023-09-23" @default.
- W2419233152 title "[Comparative genetic characteristic of vaccine strain of Yersinia pestis EV and its putative virulent derivatives]." @default.
- W2419233152 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19621820" @default.
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