FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2419243182> ?p ?o ?g. }

• W2419243182 endingPage "53" @default.
• W2419243182 startingPage "142" @default.
• W2419243182 abstract "CCND1 is amplified in around 10-20% of primary breast cancers and preferentially occurs in ER positive tumors. Though CCND1 amplification was reported predicting poor response of adjuvant tamoxifen treatment and poor prognosis in ER positive breast cancers, there were controversial data regarding the predicting value of CyclinD1 protein overexpression. In this study, we detected CyclinD1 expression using immunohistochemistry and CCND1 gene copy number using fluorescence in situ hybridization (FISH) in 355 invasive breast cancers with foci ductal carcinoma in situ (DCIS). CCND1 amplification was founded in 52 (14.6%) cases all of which showed moderate to strong CyclinD1 expression. However, majority of CCND1- tumors exhibited mild to moderate CyclinD1 staining. There were identical alterations in DCIS and the invasive lesions within the same tumor. CCND1 amplification was positively correlated with ER, PR and lymph node status (P<0.001) while negatively correlated with HER-2 amplification and p53 status (P<0.05). The majority of the CCND1 amplification/high CyclinD1 breast cancers were luminal B type while basal-like type often lost the expression of this protein. The ROC curve analysis showed that a cut-off point at which the immunostaining score of CyclinD1 is 6.5 could predict CCND1 gene amplification in breast cancer. This study indicated loss expression of CyclinD1 might be an important event in the tumorigenesis in basal-like breast cancers. Further, we confirmed an optimal cut-off point of immunostaining scores of CyclinD1 protein which could be used to predict the status of CCND1 gene and identify a subgroup of ER positive breast cancers with poor response to endocrine agents." @default.
• W2419243182 created "2016-06-24" @default.
• W2419243182 creator A5008710983 @default.
• W2419243182 creator A5011843009 @default.
• W2419243182 creator A5027475930 @default.
• W2419243182 creator A5048160277 @default.
• W2419243182 creator A5068264553 @default.
• W2419243182 creator A5080566834 @default.
• W2419243182 date "2016-01-01" @default.
• W2419243182 modified "2023-09-23" @default.
• W2419243182 title "Evaluation of CCND1 amplification and CyclinD1 expression: diffuse and strong staining of CyclinD1 could have same predictive roles as CCND1 amplification in ER positive breast cancers." @default.
• W2419243182 cites W1491028128 @default.
• W2419243182 cites W1809213319 @default.
• W2419243182 cites W1892496998 @default.
• W2419243182 cites W1961026612 @default.
• W2419243182 cites W1967252809 @default.
• W2419243182 cites W1973460244 @default.
• W2419243182 cites W1978606283 @default.
• W2419243182 cites W1981913135 @default.
• W2419243182 cites W2005156019 @default.
• W2419243182 cites W2024763413 @default.
• W2419243182 cites W2026251993 @default.
• W2419243182 cites W2032510122 @default.
• W2419243182 cites W2034896935 @default.
• W2419243182 cites W2035465043 @default.
• W2419243182 cites W2035833438 @default.
• W2419243182 cites W2036640908 @default.
• W2419243182 cites W2044702943 @default.
• W2419243182 cites W2051991584 @default.
• W2419243182 cites W2063824048 @default.
• W2419243182 cites W2065022773 @default.
• W2419243182 cites W2073397208 @default.
• W2419243182 cites W2078159546 @default.
• W2419243182 cites W2083035492 @default.
• W2419243182 cites W2087810003 @default.
• W2419243182 cites W2089122543 @default.
• W2419243182 cites W2089334378 @default.
• W2419243182 cites W2091330544 @default.
• W2419243182 cites W2097255042 @default.
• W2419243182 cites W2101979288 @default.
• W2419243182 cites W2116209951 @default.
• W2419243182 cites W2117157701 @default.
• W2419243182 cites W2117775530 @default.
• W2419243182 cites W2121664015 @default.
• W2419243182 cites W2129030357 @default.
• W2419243182 cites W2133958387 @default.
• W2419243182 cites W2147371405 @default.
• W2419243182 cites W2153933760 @default.
• W2419243182 cites W2162817699 @default.
• W2419243182 cites W2170309255 @default.
• W2419243182 cites W2259802687 @default.
• W2419243182 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4759424" @default.
• W2419243182 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27069548" @default.
• W2419243182 hasPublicationYear "2016" @default.
• W2419243182 type Work @default.
• W2419243182 sameAs 2419243182 @default.
• W2419243182 citedByCount "20" @default.
• W2419243182 countsByYear W24192431822016 @default.
• W2419243182 countsByYear W24192431822017 @default.
• W2419243182 countsByYear W24192431822018 @default.
• W2419243182 countsByYear W24192431822019 @default.
• W2419243182 countsByYear W24192431822020 @default.
• W2419243182 countsByYear W24192431822021 @default.
• W2419243182 countsByYear W24192431822022 @default.
• W2419243182 countsByYear W24192431822023 @default.
• W2419243182 crossrefType "journal-article" @default.
• W2419243182 hasAuthorship W2419243182A5008710983 @default.
• W2419243182 hasAuthorship W2419243182A5011843009 @default.
• W2419243182 hasAuthorship W2419243182A5027475930 @default.
• W2419243182 hasAuthorship W2419243182A5048160277 @default.
• W2419243182 hasAuthorship W2419243182A5068264553 @default.
• W2419243182 hasAuthorship W2419243182A5080566834 @default.
• W2419243182 hasConcept C104317684 @default.
• W2419243182 hasConcept C121608353 @default.
• W2419243182 hasConcept C126322002 @default.
• W2419243182 hasConcept C142724271 @default.
• W2419243182 hasConcept C143998085 @default.
• W2419243182 hasConcept C199835354 @default.
• W2419243182 hasConcept C204232928 @default.
• W2419243182 hasConcept C29537977 @default.
• W2419243182 hasConcept C4224716 @default.
• W2419243182 hasConcept C502942594 @default.
• W2419243182 hasConcept C530470458 @default.
• W2419243182 hasConcept C55493867 @default.
• W2419243182 hasConcept C555283112 @default.
• W2419243182 hasConcept C71924100 @default.
• W2419243182 hasConcept C7602840 @default.
• W2419243182 hasConcept C86803240 @default.
• W2419243182 hasConceptScore W2419243182C104317684 @default.
• W2419243182 hasConceptScore W2419243182C121608353 @default.
• W2419243182 hasConceptScore W2419243182C126322002 @default.
• W2419243182 hasConceptScore W2419243182C142724271 @default.
• W2419243182 hasConceptScore W2419243182C143998085 @default.
• W2419243182 hasConceptScore W2419243182C199835354 @default.
• W2419243182 hasConceptScore W2419243182C204232928 @default.
• W2419243182 hasConceptScore W2419243182C29537977 @default.
• W2419243182 hasConceptScore W2419243182C4224716 @default.
• W2419243182 hasConceptScore W2419243182C502942594 @default.

• next