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- W2419244230 endingPage "570" @default.
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- W2419244230 abstract "The histone locus body (HLB) assembles at replication-dependent histone genes and concentrates factors required for histone messenger RNA (mRNA) biosynthesis. FLASH (Flice-associated huge protein) and U7 small nuclear RNP (snRNP) are HLB components that participate in 3′ processing of the nonpolyadenylated histone mRNAs by recruiting the endonuclease CPSF-73 to histone pre-mRNA. Using transgenes to complement a FLASH mutant, we show that distinct domains of FLASH involved in U7 snRNP binding, histone pre-mRNA cleavage, and HLB localization are all required for proper FLASH function in vivo. By genetically manipulating HLB composition using mutations in FLASH, mutations in the HLB assembly factor Mxc, or depletion of the variant histone H2aV, we find that failure to concentrate FLASH and/or U7 snRNP in the HLB impairs histone pre-mRNA processing. This failure results in accumulation of small amounts of polyadenylated histone mRNA and nascent read-through transcripts at the histone locus. Thus, the HLB concentrates FLASH and U7 snRNP, promoting efficient histone mRNA biosynthesis and coupling 3′ end processing with transcription termination." @default.
- W2419244230 created "2016-06-24" @default.
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- W2419244230 date "2016-05-30" @default.
- W2419244230 modified "2023-10-15" @default.
- W2419244230 title "Concentrating pre-mRNA processing factors in the histone locus body facilitates efficient histone mRNA biogenesis" @default.
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- W2419244230 doi "https://doi.org/10.1083/jcb.201504043" @default.
- W2419244230 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4896052" @default.
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- W2419244230 hasPublicationYear "2016" @default.
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