Matches in SemOpenAlex for { <https://semopenalex.org/work/W2419291279> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2419291279 endingPage "160" @default.
- W2419291279 startingPage "155" @default.
- W2419291279 abstract "Introduction Microscopic colitis (MC) is a chronic inflammatory process observed in colon biopsies of patients with chronic aqueous diarrhea. It is called microscopic because diagnosis is determined by histological studies since the microscopic characteristics of the colon endoscopy are normal. Two patterns exist: Lymphocytic Microscopic Colitis and Collagenous Microscopic Colitis. Etiology is unknown, and the proposed pathogenic mechanisms indicate an immunological phenomenon. Based on this, the authors of this study hypothesize that lymphocytic infiltration of the lamina propria could be related to cytotoxic lymphocytes CD8 as causative agents of colon tissue damage. Objectives Prove hypothesis of immunological pathogenesis of MC. APPARATUS AND METHODS: Thirty eight (38) patients with diagnosed MC were recruited for the last four years in the Pathology Laboratory at Ricardo Palma University. Twenty two (22) colon biopsies with the most severe histological lesions were selected. These biopsies were obtained from 17 patients: 5 patients had 2 biopsies in 2 colonoscopy sessions. Biopsies were fixed in neutral formaldehyde, processed through the paraffin inclusion method, and stained with hematoxiline-eosine and Masson trichromic to distinguish collagenous tissue. Immunohistochemistry was conducted in 4- or 5-micron-thick histological sections processed through the immunoperoxidase method. Results Nineteen (19) biopsies corresponded to Lymphocytic MC and 3 to Collagenous MC. Lymphocytic MC showed intraepithelial lymphocytosis, dystrophic epithelial damage in the areas of lymphocytic infiltration, lamina propria inflammation with lymphocytes and plasma cells, and normal basement membrane. Collagenous MC showed thickened basement membrane due to the presence of a collagenous band, mild to moderate intraepithelial lymphocytosis, vacuolization,and frequent detachment of protective epithelium. Twenty two (22) biopsies were positive in the immunohistochemical studies." @default.
- W2419291279 created "2016-06-24" @default.
- W2419291279 creator A5031869825 @default.
- W2419291279 creator A5077460857 @default.
- W2419291279 creator A5079151367 @default.
- W2419291279 date "2007-04-01" @default.
- W2419291279 modified "2023-09-24" @default.
- W2419291279 title "[Microscopic colitis: pathogenesis]." @default.
- W2419291279 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17712393" @default.
- W2419291279 hasPublicationYear "2007" @default.
- W2419291279 type Work @default.
- W2419291279 sameAs 2419291279 @default.
- W2419291279 citedByCount "0" @default.
- W2419291279 crossrefType "journal-article" @default.
- W2419291279 hasAuthorship W2419291279A5031869825 @default.
- W2419291279 hasAuthorship W2419291279A5077460857 @default.
- W2419291279 hasAuthorship W2419291279A5079151367 @default.
- W2419291279 hasConcept C121608353 @default.
- W2419291279 hasConcept C126322002 @default.
- W2419291279 hasConcept C142724271 @default.
- W2419291279 hasConcept C152605822 @default.
- W2419291279 hasConcept C2775934546 @default.
- W2419291279 hasConcept C2776153500 @default.
- W2419291279 hasConcept C2777310793 @default.
- W2419291279 hasConcept C2778260677 @default.
- W2419291279 hasConcept C2778435480 @default.
- W2419291279 hasConcept C2778561856 @default.
- W2419291279 hasConcept C2778614373 @default.
- W2419291279 hasConcept C2779134260 @default.
- W2419291279 hasConcept C2779802037 @default.
- W2419291279 hasConcept C2780437304 @default.
- W2419291279 hasConcept C2780942790 @default.
- W2419291279 hasConcept C526805850 @default.
- W2419291279 hasConcept C529295009 @default.
- W2419291279 hasConcept C71924100 @default.
- W2419291279 hasConceptScore W2419291279C121608353 @default.
- W2419291279 hasConceptScore W2419291279C126322002 @default.
- W2419291279 hasConceptScore W2419291279C142724271 @default.
- W2419291279 hasConceptScore W2419291279C152605822 @default.
- W2419291279 hasConceptScore W2419291279C2775934546 @default.
- W2419291279 hasConceptScore W2419291279C2776153500 @default.
- W2419291279 hasConceptScore W2419291279C2777310793 @default.
- W2419291279 hasConceptScore W2419291279C2778260677 @default.
- W2419291279 hasConceptScore W2419291279C2778435480 @default.
- W2419291279 hasConceptScore W2419291279C2778561856 @default.
- W2419291279 hasConceptScore W2419291279C2778614373 @default.
- W2419291279 hasConceptScore W2419291279C2779134260 @default.
- W2419291279 hasConceptScore W2419291279C2779802037 @default.
- W2419291279 hasConceptScore W2419291279C2780437304 @default.
- W2419291279 hasConceptScore W2419291279C2780942790 @default.
- W2419291279 hasConceptScore W2419291279C526805850 @default.
- W2419291279 hasConceptScore W2419291279C529295009 @default.
- W2419291279 hasConceptScore W2419291279C71924100 @default.
- W2419291279 hasIssue "2" @default.
- W2419291279 hasLocation W24192912791 @default.
- W2419291279 hasLocation W24192912792 @default.
- W2419291279 hasOpenAccess W2419291279 @default.
- W2419291279 hasPrimaryLocation W24192912791 @default.
- W2419291279 hasRelatedWork W106085404 @default.
- W2419291279 hasRelatedWork W173470619 @default.
- W2419291279 hasRelatedWork W187735482 @default.
- W2419291279 hasRelatedWork W2020188954 @default.
- W2419291279 hasRelatedWork W2035373670 @default.
- W2419291279 hasRelatedWork W2037119920 @default.
- W2419291279 hasRelatedWork W2037451751 @default.
- W2419291279 hasRelatedWork W2048628132 @default.
- W2419291279 hasRelatedWork W2083462043 @default.
- W2419291279 hasRelatedWork W2313882467 @default.
- W2419291279 hasRelatedWork W2323379688 @default.
- W2419291279 hasRelatedWork W2408116241 @default.
- W2419291279 hasRelatedWork W2408892464 @default.
- W2419291279 hasRelatedWork W2413112230 @default.
- W2419291279 hasRelatedWork W2413917583 @default.
- W2419291279 hasRelatedWork W2474957900 @default.
- W2419291279 hasRelatedWork W2587870471 @default.
- W2419291279 hasRelatedWork W3148823723 @default.
- W2419291279 hasRelatedWork W3157498456 @default.
- W2419291279 hasRelatedWork W3166988676 @default.
- W2419291279 hasVolume "27" @default.
- W2419291279 isParatext "false" @default.
- W2419291279 isRetracted "false" @default.
- W2419291279 magId "2419291279" @default.
- W2419291279 workType "article" @default.