Matches in SemOpenAlex for { <https://semopenalex.org/work/W2419306670> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W2419306670 endingPage "3" @default.
- W2419306670 startingPage "900" @default.
- W2419306670 abstract "The effect of the gene polymorphism for the key enzyme's folacin metabolism pathway on plasmatic homocysteine (Hcy) levels in fertile woman was observed.The subjects were from Shaoxing City, Jiangsu province in 2012, the selection criteria for the women of childbearing age were between 20-45 years old, with an average age of 28.2 (95%CI:27.8-28.6) years old. Sample collection continued uninterrupted lasted seven days, a total of 535 samples were collected, venous blood with EDTA addition or sodium citrate to anticoagulant. After separation, the blood cells and blood plasma were cryopreserved. DNA was extracted using spin column method. All the samples were selected for the gene polymorphism testing of the key enzyme's on folate metabolism and monitoring of plasmatic Hcy level.Eight single nucleotide polymorphism (SNP) sites of methylenetetrahydrofolate reductase gene (MTHFR) , methionine synthase gene (MS) , synthetic methionine reductase gene (MSR) and cystathionine β synthase gene (CBS) were detected. It was found the genotype AA of the SNP sites-rs1801131 would result higher plasmatic Hcy levels (8.99 µmol/L) than the genotypes CC (7.81 µmol/L) and CA(8.38 µmol/L) (P < 0.01) . Similarly, the genotype TT of the SNP sites-rs1801133 was significantly responded to the increasing of Hcy levels (11.10 µmol/L) than the genotype CC (8.15 µmol/L) and CT (8.45 µmol/L), (P < 0.01) . The two sites of genotype combination of AA-TT could also result in the significant increase of Hcy levels (11.02 µmol/L) than other combined genotypes (genotypes CC-CC, CA-CC, CA-CT, AA-CC, AA-CT), especially the genotype CC-CC. And the risk factor was 1.41 (95CI:1.20-1.66) times over the genotype CC-CC.The gene mutations of two SNP sites rs1801131 and rs1801133 in MTHFR would increase Hcy levels." @default.
- W2419306670 created "2016-06-24" @default.
- W2419306670 creator A5012013841 @default.
- W2419306670 creator A5023260369 @default.
- W2419306670 creator A5053657007 @default.
- W2419306670 creator A5062040281 @default.
- W2419306670 creator A5087553017 @default.
- W2419306670 date "2014-10-01" @default.
- W2419306670 modified "2023-09-24" @default.
- W2419306670 title "[An association study between gene polymorphism of the key enzyme's folacin metabolism pathway and plasmatic homocysteine levels in fertile woman]." @default.
- W2419306670 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25573130" @default.
- W2419306670 hasPublicationYear "2014" @default.
- W2419306670 type Work @default.
- W2419306670 sameAs 2419306670 @default.
- W2419306670 citedByCount "0" @default.
- W2419306670 crossrefType "journal-article" @default.
- W2419306670 hasAuthorship W2419306670A5012013841 @default.
- W2419306670 hasAuthorship W2419306670A5023260369 @default.
- W2419306670 hasAuthorship W2419306670A5053657007 @default.
- W2419306670 hasAuthorship W2419306670A5062040281 @default.
- W2419306670 hasAuthorship W2419306670A5087553017 @default.
- W2419306670 hasConcept C104317684 @default.
- W2419306670 hasConcept C126322002 @default.
- W2419306670 hasConcept C134018914 @default.
- W2419306670 hasConcept C135763542 @default.
- W2419306670 hasConcept C139275648 @default.
- W2419306670 hasConcept C153209595 @default.
- W2419306670 hasConcept C16525657 @default.
- W2419306670 hasConcept C2777090595 @default.
- W2419306670 hasConcept C2780912031 @default.
- W2419306670 hasConcept C43563269 @default.
- W2419306670 hasConcept C515207424 @default.
- W2419306670 hasConcept C54355233 @default.
- W2419306670 hasConcept C71924100 @default.
- W2419306670 hasConcept C76252995 @default.
- W2419306670 hasConcept C80315684 @default.
- W2419306670 hasConcept C86803240 @default.
- W2419306670 hasConceptScore W2419306670C104317684 @default.
- W2419306670 hasConceptScore W2419306670C126322002 @default.
- W2419306670 hasConceptScore W2419306670C134018914 @default.
- W2419306670 hasConceptScore W2419306670C135763542 @default.
- W2419306670 hasConceptScore W2419306670C139275648 @default.
- W2419306670 hasConceptScore W2419306670C153209595 @default.
- W2419306670 hasConceptScore W2419306670C16525657 @default.
- W2419306670 hasConceptScore W2419306670C2777090595 @default.
- W2419306670 hasConceptScore W2419306670C2780912031 @default.
- W2419306670 hasConceptScore W2419306670C43563269 @default.
- W2419306670 hasConceptScore W2419306670C515207424 @default.
- W2419306670 hasConceptScore W2419306670C54355233 @default.
- W2419306670 hasConceptScore W2419306670C71924100 @default.
- W2419306670 hasConceptScore W2419306670C76252995 @default.
- W2419306670 hasConceptScore W2419306670C80315684 @default.
- W2419306670 hasConceptScore W2419306670C86803240 @default.
- W2419306670 hasIssue "10" @default.
- W2419306670 hasLocation W24193066701 @default.
- W2419306670 hasOpenAccess W2419306670 @default.
- W2419306670 hasPrimaryLocation W24193066701 @default.
- W2419306670 hasRelatedWork W115645910 @default.
- W2419306670 hasRelatedWork W1964794938 @default.
- W2419306670 hasRelatedWork W2013161968 @default.
- W2419306670 hasRelatedWork W2015312591 @default.
- W2419306670 hasRelatedWork W2016313081 @default.
- W2419306670 hasRelatedWork W2026305011 @default.
- W2419306670 hasRelatedWork W2026951187 @default.
- W2419306670 hasRelatedWork W2035076738 @default.
- W2419306670 hasRelatedWork W2327366926 @default.
- W2419306670 hasRelatedWork W2413448018 @default.
- W2419306670 hasVolume "48" @default.
- W2419306670 isParatext "false" @default.
- W2419306670 isRetracted "false" @default.
- W2419306670 magId "2419306670" @default.
- W2419306670 workType "article" @default.