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- W2419396812 abstract "Background : The prognostic value of chronic inflammation markers in patients after myocardialinfarction (MI) in the era of interventional treatment, statin and aspirin use is still unclear. Methods : The study was carried out on 107 patients with a first MI who were followed up for18 months. The end points were cardiac death, reinfarction or unstable angina pectoris. At 10 daysand at 10 weeks we measured C-reactive protein (CRP), fibrinogen, soluble intercellular adhesionmolecule 1 (sICAM-1), erythrocyte sedimentation rate (ESR), white blood cell count (WBC) andChlamydia preumoniae antibodies. Results : During the follow-up period there were 22 events. The patients were divided into twosubgroups: those with recurrent episodes and those without coronary events. Patients withrecurrent episodes had significantly higher values of CRP (7.07 vs. 3.77 mg/l, p = 0.02),ESR at 1 h (24.3 vs. 13.3 mm; p = 0.01) and sICAM-1 (287.9 vs. 260.9 ng/ml, p = 0.04)at 10 weeks following infarction. Statistical analysis showed that sICAM-1 > 270 ng/ml,CRP > 1.83 mg/l and ESR at 1 h > 14 mm measured at 10 weeks were independent riskfactors for recurrent cardiovascular events. In patients with coronary events between the 10th day and10th week there was no decrease in inflammatory indices (WBC, ESR) and a tendency towardsincreasing sICAM-1. Conclusions : Increased inflammatory markers (CRP, ESR, sICAM-1) at 10 weeks after MIare independent risk factors for recurrent cardiovascular events. Measuring CRP, ESR andsICAM-1 at this time point is useful in long-term prognosis after MI. Changes in inflammatoryindices (ESR, WBC, sICAM-1) measured at 10 days and 10 weeks following infarctionshow a different pattern in patients with and without recurrent cardiovascular events.(Cardiol J 2007; 14: 50–58)" @default.
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- W2419396812 date "2007-01-01" @default.
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- W2419396812 title "Inflammatory markers 10 weeks after myocardial infarction predict future cardiovascular events." @default.
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