Matches in SemOpenAlex for { <https://semopenalex.org/work/W2419423106> ?p ?o ?g. }
- W2419423106 endingPage "157.e17" @default.
- W2419423106 startingPage "145" @default.
- W2419423106 abstract "The type-1 ryanodine receptor (RyR1) is an intracellular calcium (Ca(2+)) release channel required for skeletal muscle contraction. Here, we present cryo-EM reconstructions of RyR1 in multiple functional states revealing the structural basis of channel gating and ligand-dependent activation. Binding sites for the channel activators Ca(2+), ATP, and caffeine were identified at interdomain interfaces of the C-terminal domain. Either ATP or Ca(2+) alone induces conformational changes in the cytoplasmic assembly (priming), without pore dilation. In contrast, in the presence of all three activating ligands, high-resolution reconstructions of open and closed states of RyR1 were obtained from the same sample, enabling analyses of conformational changes associated with gating. Gating involves global conformational changes in the cytosolic assembly accompanied by local changes in the transmembrane domain, which include bending of the S6 transmembrane segment and consequent pore dilation, displacement, and deformation of the S4-S5 linker and conformational changes in the pseudo-voltage-sensor domain." @default.
- W2419423106 created "2016-06-24" @default.
- W2419423106 creator A5004290819 @default.
- W2419423106 creator A5008339680 @default.
- W2419423106 creator A5029392839 @default.
- W2419423106 creator A5030659071 @default.
- W2419423106 creator A5042892654 @default.
- W2419423106 creator A5046511507 @default.
- W2419423106 creator A5055342333 @default.
- W2419423106 creator A5081052258 @default.
- W2419423106 creator A5088775613 @default.
- W2419423106 date "2016-09-01" @default.
- W2419423106 modified "2023-10-12" @default.
- W2419423106 title "Structural Basis for Gating and Activation of RyR1" @default.
- W2419423106 cites W1508964468 @default.
- W2419423106 cites W1571817303 @default.
- W2419423106 cites W1740533879 @default.
- W2419423106 cites W1838872057 @default.
- W2419423106 cites W1848529608 @default.
- W2419423106 cites W1891886782 @default.
- W2419423106 cites W1965117795 @default.
- W2419423106 cites W1967004359 @default.
- W2419423106 cites W1968179503 @default.
- W2419423106 cites W1972772651 @default.
- W2419423106 cites W1982295411 @default.
- W2419423106 cites W1982382901 @default.
- W2419423106 cites W1989402738 @default.
- W2419423106 cites W1989826892 @default.
- W2419423106 cites W1996876819 @default.
- W2419423106 cites W1997778815 @default.
- W2419423106 cites W2003484334 @default.
- W2419423106 cites W2003800797 @default.
- W2419423106 cites W2008388951 @default.
- W2419423106 cites W2012563911 @default.
- W2419423106 cites W2012751980 @default.
- W2419423106 cites W2015286444 @default.
- W2419423106 cites W2018806883 @default.
- W2419423106 cites W2021630348 @default.
- W2419423106 cites W2022558995 @default.
- W2419423106 cites W2028095647 @default.
- W2419423106 cites W2029995670 @default.
- W2419423106 cites W2031533756 @default.
- W2419423106 cites W2033039093 @default.
- W2419423106 cites W2033364500 @default.
- W2419423106 cites W2043901383 @default.
- W2419423106 cites W2047573789 @default.
- W2419423106 cites W2051340899 @default.
- W2419423106 cites W2052495204 @default.
- W2419423106 cites W2054770020 @default.
- W2419423106 cites W2056911370 @default.
- W2419423106 cites W2061811233 @default.
- W2419423106 cites W2068650437 @default.
- W2419423106 cites W2071056181 @default.
- W2419423106 cites W2076384379 @default.
- W2419423106 cites W2076449818 @default.
- W2419423106 cites W2084824108 @default.
- W2419423106 cites W2086812659 @default.
- W2419423106 cites W2096851276 @default.
- W2419423106 cites W2103972113 @default.
- W2419423106 cites W2104234755 @default.
- W2419423106 cites W2107748489 @default.
- W2419423106 cites W2110283222 @default.
- W2419423106 cites W2114749318 @default.
- W2419423106 cites W2120772351 @default.
- W2419423106 cites W2124026197 @default.
- W2419423106 cites W2129220177 @default.
- W2419423106 cites W2132629607 @default.
- W2419423106 cites W2132926880 @default.
- W2419423106 cites W2141385342 @default.
- W2419423106 cites W2148941629 @default.
- W2419423106 cites W2149360962 @default.
- W2419423106 cites W215096444 @default.
- W2419423106 cites W2152562710 @default.
- W2419423106 cites W2162999390 @default.
- W2419423106 cites W2173669563 @default.
- W2419423106 cites W2194464187 @default.
- W2419423106 cites W2226437153 @default.
- W2419423106 cites W2269323417 @default.
- W2419423106 cites W2395427107 @default.
- W2419423106 cites W2412953486 @default.
- W2419423106 cites W2953320394 @default.
- W2419423106 cites W2963188324 @default.
- W2419423106 cites W4255828785 @default.
- W2419423106 cites W4294748274 @default.
- W2419423106 doi "https://doi.org/10.1016/j.cell.2016.08.075" @default.
- W2419423106 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5142848" @default.
- W2419423106 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27662087" @default.
- W2419423106 hasPublicationYear "2016" @default.
- W2419423106 type Work @default.
- W2419423106 sameAs 2419423106 @default.
- W2419423106 citedByCount "284" @default.
- W2419423106 countsByYear W24194231062016 @default.
- W2419423106 countsByYear W24194231062017 @default.
- W2419423106 countsByYear W24194231062018 @default.
- W2419423106 countsByYear W24194231062019 @default.
- W2419423106 countsByYear W24194231062020 @default.
- W2419423106 countsByYear W24194231062021 @default.
- W2419423106 countsByYear W24194231062022 @default.