Matches in SemOpenAlex for { <https://semopenalex.org/work/W2419438285> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W2419438285 endingPage "4" @default.
- W2419438285 startingPage "552" @default.
- W2419438285 abstract "We describe a 76-year-old male patient who developed a life-threatening acute hepatotoxicity possibly caused by flutamide, an antiandrogen drug given during the previous 10 months, in the scenario of a brief moderate hypotension secondary to atrial flutter. There was a sudden increase of liver enzyme levels AST = 4.521 IU/L, ALT = 1.716 IU/L (normal values 0-37 and 0-40 respectively), prothrombin activity decreased to 16%, and also felt the platelet count, with significant haemorrhages. We hypothesize this was triggered as a consequence of the transient diminished supply of oxygen to the subclinically flutamide-damaged hepatocytes by the well-known mechanism of the cytochrome P450 (3A and 1A)-mediated formation of electrophilic metabolites, and the inhibitory effect of flutamide on mitochondrial respiration and ATP formation." @default.
- W2419438285 created "2016-06-24" @default.
- W2419438285 creator A5042999466 @default.
- W2419438285 creator A5060955118 @default.
- W2419438285 creator A5072226201 @default.
- W2419438285 date "1996-11-01" @default.
- W2419438285 modified "2023-09-23" @default.
- W2419438285 title "[Hepatoxicity caused by flutamide increased by hypotensive situation?]." @default.
- W2419438285 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9019217" @default.
- W2419438285 hasPublicationYear "1996" @default.
- W2419438285 type Work @default.
- W2419438285 sameAs 2419438285 @default.
- W2419438285 citedByCount "0" @default.
- W2419438285 crossrefType "journal-article" @default.
- W2419438285 hasAuthorship W2419438285A5042999466 @default.
- W2419438285 hasAuthorship W2419438285A5060955118 @default.
- W2419438285 hasAuthorship W2419438285A5072226201 @default.
- W2419438285 hasConcept C121608353 @default.
- W2419438285 hasConcept C126322002 @default.
- W2419438285 hasConcept C134018914 @default.
- W2419438285 hasConcept C142724271 @default.
- W2419438285 hasConcept C204787440 @default.
- W2419438285 hasConcept C27081682 @default.
- W2419438285 hasConcept C2778313021 @default.
- W2419438285 hasConcept C2779322244 @default.
- W2419438285 hasConcept C2780035454 @default.
- W2419438285 hasConcept C2780192828 @default.
- W2419438285 hasConcept C2780434524 @default.
- W2419438285 hasConcept C3020359197 @default.
- W2419438285 hasConcept C61367390 @default.
- W2419438285 hasConcept C71924100 @default.
- W2419438285 hasConcept C98274493 @default.
- W2419438285 hasConceptScore W2419438285C121608353 @default.
- W2419438285 hasConceptScore W2419438285C126322002 @default.
- W2419438285 hasConceptScore W2419438285C134018914 @default.
- W2419438285 hasConceptScore W2419438285C142724271 @default.
- W2419438285 hasConceptScore W2419438285C204787440 @default.
- W2419438285 hasConceptScore W2419438285C27081682 @default.
- W2419438285 hasConceptScore W2419438285C2778313021 @default.
- W2419438285 hasConceptScore W2419438285C2779322244 @default.
- W2419438285 hasConceptScore W2419438285C2780035454 @default.
- W2419438285 hasConceptScore W2419438285C2780192828 @default.
- W2419438285 hasConceptScore W2419438285C2780434524 @default.
- W2419438285 hasConceptScore W2419438285C3020359197 @default.
- W2419438285 hasConceptScore W2419438285C61367390 @default.
- W2419438285 hasConceptScore W2419438285C71924100 @default.
- W2419438285 hasConceptScore W2419438285C98274493 @default.
- W2419438285 hasIssue "11" @default.
- W2419438285 hasLocation W24194382851 @default.
- W2419438285 hasOpenAccess W2419438285 @default.
- W2419438285 hasPrimaryLocation W24194382851 @default.
- W2419438285 hasRelatedWork W1972695434 @default.
- W2419438285 hasRelatedWork W1973860147 @default.
- W2419438285 hasRelatedWork W1987903254 @default.
- W2419438285 hasRelatedWork W1999093110 @default.
- W2419438285 hasRelatedWork W2012742352 @default.
- W2419438285 hasRelatedWork W2017379168 @default.
- W2419438285 hasRelatedWork W2053478678 @default.
- W2419438285 hasRelatedWork W2059070336 @default.
- W2419438285 hasRelatedWork W2130806298 @default.
- W2419438285 hasRelatedWork W2134349385 @default.
- W2419438285 hasVolume "13" @default.
- W2419438285 isParatext "false" @default.
- W2419438285 isRetracted "false" @default.
- W2419438285 magId "2419438285" @default.
- W2419438285 workType "article" @default.