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• W2419482128 abstract "We review how polyreactive natural IgM autoantibodies (IgM-NAA) protect the host from invading micro-organisms and host neo-antigens that are constantly being produced by oxidation mechanisms and cell apoptosis. Secondly, we discuss how IgM-NAA and IgM-ALA inhibits auto-immune inflammation by anti-idiotypic mechanisms, enhancing removal of apoptotic cells, masking neo-antigens and regulating the function of dendritic cells (DC) and effector cells. Thirdly, we review how natural IgM prevents autoimmune disorders arising from pathogenic IgG autoantibodies, triggered by genetic mechanisms (e.g. SLE) or micro-organisms, as well as by auto reactive B and T cells that have escaped tolerance mechanisms. Studies in IgM knockout mice have clearly demonstrated that regulatory B and T cells require IgM to effectively regulate inflammation mediated by innate, adaptive and auto-immune mechanisms. It is therefore not surprising why the host positively selects such autoreactive B1 cells that generate protective IgM-NAA, which are also evolutionarily conserved. Fourthly, we show that IgM-ALA levels and repertoire can vary in normal humans and disease states and this variation may partly explain the observed differences in the inflammatory response after infection, ischemic injury or after a transplant. We also show how protective IgM-NAA can be rendered pathogenic under non-physiological conditions. We also review IgG-NAA that are more abundant than IgM-NAA in plasma. However, we need to understand if the (Fab)2 region of IgG-NAA has physiological relevance in non-disease states, as in plasma, their functional activity is blocked by IgM-NAA having anti-idiotypic activity. Some IgG NAA are produced by B2 cells that have escaped tolerance mechanisms and we show how such pathogenic IgG-NAA are regulated to prevent autoimmune disease. The Fc region of IgG-NAA can influence inflammation and B cell function in-vivo by binding to activating and inhibitory FcR. IgM-NAA has therapeutic potential. Polyclonal IgM infusions can be used to abrogate on-going inflammation. Additionally, inflammation arising after ischemia induced kidney injury e.g. during high-risk elective cardiac surgery or after allograft transplantation, can be abrogated by pre-emptively infusing polyclonal IgM or DC pretreated ex-vivo with IgM or by increasing in-vivo IgM with a vaccine approach. Cell therapy is appealing as less IgM will be required." @default.
• W2419482128 created "2016-06-24" @default.
• W2419482128 creator A5002436965 @default.
• W2419482128 date "2016-06-06" @default.
• W2419482128 modified "2023-10-16" @default.
• W2419482128 title "Role of Natural Autoantibodies and Natural IgM Anti-Leucocyte Autoantibodies in Health and Disease" @default.
• W2419482128 cites W1242608901 @default.
• W2419482128 cites W1482061796 @default.
• W2419482128 cites W1482494509 @default.
• W2419482128 cites W1483018379 @default.
• W2419482128 cites W1490131068 @default.
• W2419482128 cites W1508436155 @default.
• W2419482128 cites W1538950484 @default.
• W2419482128 cites W1554784279 @default.
• W2419482128 cites W1563142381 @default.
• W2419482128 cites W1568395771 @default.
• W2419482128 cites W1569112678 @default.
• W2419482128 cites W1572191362 @default.
• W2419482128 cites W1573250191 @default.
• W2419482128 cites W1575509548 @default.
• W2419482128 cites W1578803305 @default.
• W2419482128 cites W1579988068 @default.
• W2419482128 cites W1583001054 @default.
• W2419482128 cites W1597594068 @default.
• W2419482128 cites W161265260 @default.
• W2419482128 cites W1644903522 @default.
• W2419482128 cites W1696728861 @default.
• W2419482128 cites W1752304426 @default.
• W2419482128 cites W1765210549 @default.
• W2419482128 cites W1886006934 @default.
• W2419482128 cites W1891716036 @default.
• W2419482128 cites W1906307758 @default.
• W2419482128 cites W1927979795 @default.
• W2419482128 cites W1938885059 @default.
• W2419482128 cites W1952811618 @default.
• W2419482128 cites W1963518447 @default.
• W2419482128 cites W1964701274 @default.
• W2419482128 cites W1964812677 @default.
• W2419482128 cites W1965113185 @default.
• W2419482128 cites W1966844155 @default.
• W2419482128 cites W1967102079 @default.
• W2419482128 cites W1967811983 @default.
• W2419482128 cites W1967850547 @default.
• W2419482128 cites W1970228545 @default.
• W2419482128 cites W1970688787 @default.
• W2419482128 cites W1971680376 @default.
• W2419482128 cites W1972715229 @default.
• W2419482128 cites W1980082178 @default.
• W2419482128 cites W1981288431 @default.
• W2419482128 cites W1982048381 @default.
• W2419482128 cites W1983347503 @default.
• W2419482128 cites W1984046448 @default.
• W2419482128 cites W1984729665 @default.
• W2419482128 cites W1987205645 @default.
• W2419482128 cites W1988265487 @default.
• W2419482128 cites W1988583408 @default.
• W2419482128 cites W1989018645 @default.
• W2419482128 cites W1991249040 @default.
• W2419482128 cites W1992467185 @default.
• W2419482128 cites W1992608176 @default.
• W2419482128 cites W1992707199 @default.
• W2419482128 cites W1993609762 @default.
• W2419482128 cites W1995025510 @default.
• W2419482128 cites W1996644394 @default.
• W2419482128 cites W1999753166 @default.
• W2419482128 cites W2000270871 @default.
• W2419482128 cites W2001052062 @default.
• W2419482128 cites W2001947430 @default.
• W2419482128 cites W2002697968 @default.
• W2419482128 cites W2002705228 @default.
• W2419482128 cites W2008406050 @default.
• W2419482128 cites W2009442193 @default.
• W2419482128 cites W2009726358 @default.
• W2419482128 cites W2011783496 @default.
• W2419482128 cites W2017739906 @default.
• W2419482128 cites W2019274057 @default.
• W2419482128 cites W2019365059 @default.
• W2419482128 cites W2020438152 @default.
• W2419482128 cites W2021916493 @default.
• W2419482128 cites W2022169378 @default.
• W2419482128 cites W2023502808 @default.
• W2419482128 cites W2025234694 @default.
• W2419482128 cites W2026647479 @default.
• W2419482128 cites W2027133133 @default.
• W2419482128 cites W2027226325 @default.
• W2419482128 cites W2028317299 @default.
• W2419482128 cites W2035965693 @default.
• W2419482128 cites W2036126415 @default.
• W2419482128 cites W2036638514 @default.
• W2419482128 cites W2036710073 @default.
• W2419482128 cites W2037739372 @default.
• W2419482128 cites W2038085074 @default.
• W2419482128 cites W2042797177 @default.
• W2419482128 cites W2043186109 @default.
• W2419482128 cites W2044098624 @default.
• W2419482128 cites W2044293547 @default.
• W2419482128 cites W2044485561 @default.
• W2419482128 cites W2045594979 @default.
• W2419482128 cites W2045641853 @default.
• W2419482128 cites W2046456172 @default.

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