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- W2419578081 abstract "Experimental cardiomyopathy was produced by isoprenaline (2 x 80 mg/kg sc daily for 2 days). The degree of myocardial damage was evaluated histopathologically. In the damaged cardiac muscle the incorporation of 14C-adenine was impaired, the adenylate cyclase activity was diminished and the total contents of cAMP and 14C-cAMP formed from intracellular 14C-adenine metabolism were reduced. No significant changes in the activity of phosphodiesterase were found. This indicates that cAMP synthesis is impaired as a result of decreased utilization of the ATP pool formed from exogenous adenine in the cardiac muscle damaged by isoprenaline." @default.
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- W2419578081 date "1981-01-01" @default.
- W2419578081 modified "2023-09-23" @default.
- W2419578081 title "Incorporation of 14C-adenine to cyclic 3',5'-AMP of cardiac muscle in isoprenaline-induced experimental cardiomyopathy." @default.
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