Matches in SemOpenAlex for { <https://semopenalex.org/work/W2419678669> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2419678669 endingPage "C473" @default.
- W2419678669 startingPage "C468" @default.
- W2419678669 abstract "The present study was undertaken to determine the extent to which cyclic nucleotide-induced relaxation in the intact rat aorta is mediated at the level of the contractile system. The relaxant effects of the cyclic nucleotide analogues [8-bromoguanosine 3',5'-cyclic monophosphate (8-BrcGMP) and dibutyryladenosine 3',5'-cyclic monophosphate (DBcAMP)] and forskolin were examined in both the intact vessel and a Triton X-100-skinned preparation of rat thoracic aorta. Relaxation of a norepinephrine-induced contraction was essentially complete 30 min after the addition of 50 microM 8-BrcGMP [% relaxation = 87.2 +/- 4.4% (n = 4)], 100 microM DBcAMP [98.2 +/- 1.2% (n = 4)], and 1 microM forskolin [107.0 +/- 3.3% (n = 5)]. These same doses were ineffective in relaxing precontracted skinned rat aortic rings compared with the relaxation achieved in the intact vessel. The largest relaxation in the skinned aortas was achieved with the addition of 1 microM forskolin [17.4 +/- 1.5% (n = 4)]. The addition of catalytic subunit of cAMP-dependent protein kinase had no effect on isometric tension in the precontracted skinned aorta. Preincubation with the cyclic nucleotide analogues or forskolin in a low-Ca2+ solution (pCa less than 8) was also ineffective in inhibiting subsequent isometric tension development. Our results suggest that only a very small fraction of the relaxation with cyclic nucleotides and forskolin in the intact rat aorta is due to the action of these agents at the level of the contractile system." @default.
- W2419678669 created "2016-06-24" @default.
- W2419678669 creator A5023673225 @default.
- W2419678669 creator A5032898310 @default.
- W2419678669 date "1986-03-01" @default.
- W2419678669 modified "2023-09-25" @default.
- W2419678669 title "Effects of forskolin and cyclic nucleotides on isometric force in rat aorta" @default.
- W2419678669 cites W1596707465 @default.
- W2419678669 cites W1970552748 @default.
- W2419678669 cites W1975827500 @default.
- W2419678669 cites W1991982812 @default.
- W2419678669 cites W1996832662 @default.
- W2419678669 cites W1997296447 @default.
- W2419678669 cites W1998687037 @default.
- W2419678669 cites W2015368999 @default.
- W2419678669 cites W2019391739 @default.
- W2419678669 cites W2033552040 @default.
- W2419678669 cites W2040075704 @default.
- W2419678669 cites W2046045814 @default.
- W2419678669 cites W2046953488 @default.
- W2419678669 cites W2053458807 @default.
- W2419678669 cites W2053837580 @default.
- W2419678669 cites W2065203161 @default.
- W2419678669 cites W2072277296 @default.
- W2419678669 cites W2077798575 @default.
- W2419678669 cites W2122287961 @default.
- W2419678669 cites W2133975951 @default.
- W2419678669 cites W2151059125 @default.
- W2419678669 cites W2148174131 @default.
- W2419678669 doi "https://doi.org/10.1152/ajpcell.1986.250.3.c468" @default.
- W2419678669 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3006507" @default.
- W2419678669 hasPublicationYear "1986" @default.
- W2419678669 type Work @default.
- W2419678669 sameAs 2419678669 @default.
- W2419678669 citedByCount "23" @default.
- W2419678669 countsByYear W24196786692014 @default.
- W2419678669 countsByYear W24196786692020 @default.
- W2419678669 crossrefType "journal-article" @default.
- W2419678669 hasAuthorship W2419678669A5023673225 @default.
- W2419678669 hasAuthorship W2419678669A5032898310 @default.
- W2419678669 hasConcept C103486182 @default.
- W2419678669 hasConcept C104317684 @default.
- W2419678669 hasConcept C12554922 @default.
- W2419678669 hasConcept C126322002 @default.
- W2419678669 hasConcept C134018914 @default.
- W2419678669 hasConcept C163415756 @default.
- W2419678669 hasConcept C170493617 @default.
- W2419678669 hasConcept C185592680 @default.
- W2419678669 hasConcept C2776864027 @default.
- W2419678669 hasConcept C2778524494 @default.
- W2419678669 hasConcept C2779276759 @default.
- W2419678669 hasConcept C2779768347 @default.
- W2419678669 hasConcept C2779980429 @default.
- W2419678669 hasConcept C512185932 @default.
- W2419678669 hasConcept C55493867 @default.
- W2419678669 hasConcept C555293320 @default.
- W2419678669 hasConcept C71924100 @default.
- W2419678669 hasConcept C86803240 @default.
- W2419678669 hasConceptScore W2419678669C103486182 @default.
- W2419678669 hasConceptScore W2419678669C104317684 @default.
- W2419678669 hasConceptScore W2419678669C12554922 @default.
- W2419678669 hasConceptScore W2419678669C126322002 @default.
- W2419678669 hasConceptScore W2419678669C134018914 @default.
- W2419678669 hasConceptScore W2419678669C163415756 @default.
- W2419678669 hasConceptScore W2419678669C170493617 @default.
- W2419678669 hasConceptScore W2419678669C185592680 @default.
- W2419678669 hasConceptScore W2419678669C2776864027 @default.
- W2419678669 hasConceptScore W2419678669C2778524494 @default.
- W2419678669 hasConceptScore W2419678669C2779276759 @default.
- W2419678669 hasConceptScore W2419678669C2779768347 @default.
- W2419678669 hasConceptScore W2419678669C2779980429 @default.
- W2419678669 hasConceptScore W2419678669C512185932 @default.
- W2419678669 hasConceptScore W2419678669C55493867 @default.
- W2419678669 hasConceptScore W2419678669C555293320 @default.
- W2419678669 hasConceptScore W2419678669C71924100 @default.
- W2419678669 hasConceptScore W2419678669C86803240 @default.
- W2419678669 hasIssue "3" @default.
- W2419678669 hasLocation W24196786691 @default.
- W2419678669 hasLocation W24196786692 @default.
- W2419678669 hasOpenAccess W2419678669 @default.
- W2419678669 hasPrimaryLocation W24196786691 @default.
- W2419678669 hasRelatedWork W1975960681 @default.
- W2419678669 hasRelatedWork W2054038633 @default.
- W2419678669 hasRelatedWork W2067735178 @default.
- W2419678669 hasRelatedWork W2228195995 @default.
- W2419678669 hasRelatedWork W2387360771 @default.
- W2419678669 hasRelatedWork W2407212191 @default.
- W2419678669 hasRelatedWork W2410699414 @default.
- W2419678669 hasRelatedWork W2419092761 @default.
- W2419678669 hasRelatedWork W2419678669 @default.
- W2419678669 hasRelatedWork W3146542618 @default.
- W2419678669 hasVolume "250" @default.
- W2419678669 isParatext "false" @default.
- W2419678669 isRetracted "false" @default.
- W2419678669 magId "2419678669" @default.
- W2419678669 workType "article" @default.