Matches in SemOpenAlex for { <https://semopenalex.org/work/W2420121570> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2420121570 endingPage "45" @default.
- W2420121570 startingPage "837" @default.
- W2420121570 abstract "Histamine and recombinant granulocyte colony-stimulating factor (rG-CSF) stimulated the differentiation of murine myeloblasts and promyelocytes to mature neutrophils. In connection with this, myeloperoxidase activity of these progenitor cells was decreased by either histamine or rG-CSF treatment. After pretreatment with histamine at 1 microM, both differentiation and the decrease in myeloperoxidase activity of myeloblasts and promyelocytes induced by rG-CSF were significantly augmented. Binding assays using 125I-labeled rG-CSF showed that the number of rG-CSF binding sites on the surface of neutrophil progenitor cells increased after histamine treatment. The histamine-induced increase in rG-CSF binding appeared to be definitely through H2 receptors. Furthermore, the increase in rG-CSF binding sites due to histamine treatment seemed to take place in association with the externalization of G-CSF receptors, because 1) the binding increase was observed in the presence of cycloheximide, 2) no concomitant increase in [3H]leucine uptake was elicited, and 3) colchicine and cytochalasin D effectively prevented the increase in rG-CSF binding due to histamine. In neutrophil progenitors, cAMP contents increased very rapidly and significantly after either histamine or rG-CSF treatment. Moreover, dibutyryl-cAMP increased rG-CSF binding to neutrophil progenitor cells in a dose-dependent fashion. However, when progenitor cells were pretreated with protein kinase A inhibitors, the histamine-induced increase in rG-CSF binding was remarkably decreased. This result seems to indicate that the stimulatory effects of histamine on rG-CSF binding to progenitor cells are intimately related to the cAMP-protein kinase A system in neutrophil progenitors. Moreover, c-myc mRNA expression in neutrophil progenitors was markedly reduced by either histamine or rG-CSF treatment. It was concluded that rG-CSF-induced differentiation of murine neutrophil progenitors was augmented by histamine pretreatment mainly due to an increase in rG-CSF receptors on these cells and this increase might be related to the externalization of rG-CSF receptors." @default.
- W2420121570 created "2016-06-24" @default.
- W2420121570 creator A5028028265 @default.
- W2420121570 creator A5032740722 @default.
- W2420121570 creator A5048257604 @default.
- W2420121570 creator A5069512472 @default.
- W2420121570 date "1994-05-01" @default.
- W2420121570 modified "2023-09-23" @default.
- W2420121570 title "Reinforcement effect of histamine on the differentiation of murine myeloblasts and promyelocytes: externalization of granulocyte colony-stimulating factor receptors induced by histamine." @default.
- W2420121570 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7514713" @default.
- W2420121570 hasPublicationYear "1994" @default.
- W2420121570 type Work @default.
- W2420121570 sameAs 2420121570 @default.
- W2420121570 citedByCount "6" @default.
- W2420121570 countsByYear W24201215702018 @default.
- W2420121570 crossrefType "journal-article" @default.
- W2420121570 hasAuthorship W2420121570A5028028265 @default.
- W2420121570 hasAuthorship W2420121570A5032740722 @default.
- W2420121570 hasAuthorship W2420121570A5048257604 @default.
- W2420121570 hasAuthorship W2420121570A5069512472 @default.
- W2420121570 hasConcept C10335311 @default.
- W2420121570 hasConcept C109159458 @default.
- W2420121570 hasConcept C1122143 @default.
- W2420121570 hasConcept C126322002 @default.
- W2420121570 hasConcept C134018914 @default.
- W2420121570 hasConcept C14942488 @default.
- W2420121570 hasConcept C153911025 @default.
- W2420121570 hasConcept C159545944 @default.
- W2420121570 hasConcept C170493617 @default.
- W2420121570 hasConcept C185592680 @default.
- W2420121570 hasConcept C201750760 @default.
- W2420121570 hasConcept C2776885963 @default.
- W2420121570 hasConcept C2777983669 @default.
- W2420121570 hasConcept C28328180 @default.
- W2420121570 hasConcept C30862142 @default.
- W2420121570 hasConcept C34400551 @default.
- W2420121570 hasConcept C71924100 @default.
- W2420121570 hasConcept C86803240 @default.
- W2420121570 hasConcept C95444343 @default.
- W2420121570 hasConcept C98274493 @default.
- W2420121570 hasConceptScore W2420121570C10335311 @default.
- W2420121570 hasConceptScore W2420121570C109159458 @default.
- W2420121570 hasConceptScore W2420121570C1122143 @default.
- W2420121570 hasConceptScore W2420121570C126322002 @default.
- W2420121570 hasConceptScore W2420121570C134018914 @default.
- W2420121570 hasConceptScore W2420121570C14942488 @default.
- W2420121570 hasConceptScore W2420121570C153911025 @default.
- W2420121570 hasConceptScore W2420121570C159545944 @default.
- W2420121570 hasConceptScore W2420121570C170493617 @default.
- W2420121570 hasConceptScore W2420121570C185592680 @default.
- W2420121570 hasConceptScore W2420121570C201750760 @default.
- W2420121570 hasConceptScore W2420121570C2776885963 @default.
- W2420121570 hasConceptScore W2420121570C2777983669 @default.
- W2420121570 hasConceptScore W2420121570C28328180 @default.
- W2420121570 hasConceptScore W2420121570C30862142 @default.
- W2420121570 hasConceptScore W2420121570C34400551 @default.
- W2420121570 hasConceptScore W2420121570C71924100 @default.
- W2420121570 hasConceptScore W2420121570C86803240 @default.
- W2420121570 hasConceptScore W2420121570C95444343 @default.
- W2420121570 hasConceptScore W2420121570C98274493 @default.
- W2420121570 hasIssue "5" @default.
- W2420121570 hasLocation W24201215701 @default.
- W2420121570 hasOpenAccess W2420121570 @default.
- W2420121570 hasPrimaryLocation W24201215701 @default.
- W2420121570 hasRelatedWork W122033644 @default.
- W2420121570 hasRelatedWork W178946232 @default.
- W2420121570 hasRelatedWork W1970895266 @default.
- W2420121570 hasRelatedWork W2005373223 @default.
- W2420121570 hasRelatedWork W2022109775 @default.
- W2420121570 hasRelatedWork W2043572826 @default.
- W2420121570 hasRelatedWork W2420121570 @default.
- W2420121570 hasRelatedWork W4238826620 @default.
- W2420121570 hasRelatedWork W639473593 @default.
- W2420121570 hasRelatedWork W2006627038 @default.
- W2420121570 hasVolume "45" @default.
- W2420121570 isParatext "false" @default.
- W2420121570 isRetracted "false" @default.
- W2420121570 magId "2420121570" @default.
- W2420121570 workType "article" @default.