FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2420204239> ?p ?o ?g. }

• W2420204239 abstract "Our previous study demonstrated a disparity of action between two established pharmacological modulators of the same calcium (Ca2+) release channel, the ryanodine receptor (RyR). Specifically, we observed that caffeine sensitivity was elicited at earlier stages of development than that of ryanodine. In the present study, we offer a hypothesis to resolve this paradox. We provide evidence that ryanodine acts as a pure uncompetitive inhibitor of Ca2+ transport, with respect to Ca2+ itself. This explains why little ryanodine inhibition was observed at low Ca2+ concentrations, while maximal ryanodine inhibition was observed at saturating Ca2+ concentrations. In order to exclude the possibility of nonspecific ryanodine actions as an alternative explanation, we established the phenomenon of capacitative calcium entry (CCE) for L6 cells. Since it is known that CCE is inversely correlated with [Ca2+] of the ER/SR lumen, the extent of CCE is therefore an indirect measure of Ca2+ concentration within the SR. We also demonstrated the functional pathway for Ca2+ entry. Employing pharmacological inhibitors, we found that a T-type plasma membrane channel was predominant in the myoblasts, while an L-type channel was predominant in the adult myotubes. Our data using these inhibitors made nonspecific ryanodine actions an unlikely explanation of the disparity in action between ryanodine and caffeine. Moreover, we found no evidence that inositol trisphosphate, a proposed regulator of CCE for other cells, could influence CCE in L6 cells. We conclude that the disparity between caffeine and ryanodine can be explained by Ca2+ dependence of ryanodine action. This study may also offer an explanation of other studies showing unclear actions of ryanodine binding and action." @default.
• W2420204239 created "2016-06-24" @default.
• W2420204239 creator A5012355195 @default.
• W2420204239 creator A5086462615 @default.
• W2420204239 date "2001-02-01" @default.
• W2420204239 modified "2023-09-24" @default.
• W2420204239 title "Changes in Ryanodine Receptor-Mediated Calcium Release During Skeletal Muscle Differentiation. II. Resolution of a Caffeine-Ryanodine Paradox" @default.
• W2420204239 cites W1411083358 @default.
• W2420204239 cites W1513064825 @default.
• W2420204239 cites W1533966875 @default.
• W2420204239 cites W1874327812 @default.
• W2420204239 cites W1986801182 @default.
• W2420204239 cites W1990914417 @default.
• W2420204239 cites W1997403679 @default.
• W2420204239 cites W2004656599 @default.
• W2420204239 cites W2012247789 @default.
• W2420204239 cites W2013939572 @default.
• W2420204239 cites W2015012351 @default.
• W2420204239 cites W2017178896 @default.
• W2420204239 cites W2032770343 @default.
• W2420204239 cites W2035885166 @default.
• W2420204239 cites W2055167313 @default.
• W2420204239 cites W2068448598 @default.
• W2420204239 cites W2069954747 @default.
• W2420204239 cites W2080955459 @default.
• W2420204239 cites W2081090062 @default.
• W2420204239 cites W2086678064 @default.
• W2420204239 cites W2090362748 @default.
• W2420204239 cites W2091441992 @default.
• W2420204239 cites W2112446953 @default.
• W2420204239 cites W2141259391 @default.
• W2420204239 cites W2141260882 @default.
• W2420204239 cites W2421448671 @default.
• W2420204239 cites W326257236 @default.
• W2420204239 cites W4237018307 @default.
• W2420204239 doi "https://doi.org/10.1177/153537020122600209" @default.
• W2420204239 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11446435" @default.
• W2420204239 hasPublicationYear "2001" @default.
• W2420204239 type Work @default.
• W2420204239 sameAs 2420204239 @default.
• W2420204239 citedByCount "9" @default.
• W2420204239 countsByYear W24202042392015 @default.
• W2420204239 countsByYear W24202042392016 @default.
• W2420204239 crossrefType "journal-article" @default.
• W2420204239 hasAuthorship W2420204239A5012355195 @default.
• W2420204239 hasAuthorship W2420204239A5086462615 @default.
• W2420204239 hasConcept C113217602 @default.
• W2420204239 hasConcept C12554922 @default.
• W2420204239 hasConcept C126322002 @default.
• W2420204239 hasConcept C134018914 @default.
• W2420204239 hasConcept C170493617 @default.
• W2420204239 hasConcept C185592680 @default.
• W2420204239 hasConcept C18699975 @default.
• W2420204239 hasConcept C207200792 @default.
• W2420204239 hasConcept C2777427919 @default.
• W2420204239 hasConcept C2778500429 @default.
• W2420204239 hasConcept C519063684 @default.
• W2420204239 hasConcept C55493867 @default.
• W2420204239 hasConcept C71924100 @default.
• W2420204239 hasConcept C86803240 @default.
• W2420204239 hasConceptScore W2420204239C113217602 @default.
• W2420204239 hasConceptScore W2420204239C12554922 @default.
• W2420204239 hasConceptScore W2420204239C126322002 @default.
• W2420204239 hasConceptScore W2420204239C134018914 @default.
• W2420204239 hasConceptScore W2420204239C170493617 @default.
• W2420204239 hasConceptScore W2420204239C185592680 @default.
• W2420204239 hasConceptScore W2420204239C18699975 @default.
• W2420204239 hasConceptScore W2420204239C207200792 @default.
• W2420204239 hasConceptScore W2420204239C2777427919 @default.
• W2420204239 hasConceptScore W2420204239C2778500429 @default.
• W2420204239 hasConceptScore W2420204239C519063684 @default.
• W2420204239 hasConceptScore W2420204239C55493867 @default.
• W2420204239 hasConceptScore W2420204239C71924100 @default.
• W2420204239 hasConceptScore W2420204239C86803240 @default.
• W2420204239 hasLocation W24202042391 @default.
• W2420204239 hasLocation W24202042392 @default.
• W2420204239 hasOpenAccess W2420204239 @default.
• W2420204239 hasPrimaryLocation W24202042391 @default.
• W2420204239 hasRelatedWork W1782576348 @default.
• W2420204239 hasRelatedWork W1979142886 @default.
• W2420204239 hasRelatedWork W2005946138 @default.
• W2420204239 hasRelatedWork W2013324232 @default.
• W2420204239 hasRelatedWork W2021105798 @default.
• W2420204239 hasRelatedWork W2036821662 @default.
• W2420204239 hasRelatedWork W2053069911 @default.
• W2420204239 hasRelatedWork W2075984067 @default.
• W2420204239 hasRelatedWork W2082262140 @default.
• W2420204239 hasRelatedWork W2086449013 @default.
• W2420204239 hasRelatedWork W2094910653 @default.
• W2420204239 hasRelatedWork W2109964997 @default.
• W2420204239 hasRelatedWork W2114632792 @default.
• W2420204239 hasRelatedWork W2114727629 @default.
• W2420204239 hasRelatedWork W2118241690 @default.
• W2420204239 hasRelatedWork W2128113643 @default.
• W2420204239 hasRelatedWork W2141260882 @default.
• W2420204239 hasRelatedWork W2162451481 @default.
• W2420204239 hasRelatedWork W2767777174 @default.
• W2420204239 hasRelatedWork W633478370 @default.
• W2420204239 isParatext "false" @default.
• W2420204239 isRetracted "false" @default.

• next