Matches in SemOpenAlex for { <https://semopenalex.org/work/W2420462095> ?p ?o ?g. }
- W2420462095 endingPage "878" @default.
- W2420462095 startingPage "871" @default.
- W2420462095 abstract "Objectives: Recent studies have shown strong correlation of pathologic complete response (pCR) to neoadjuvant chemotherapy with survival and prognosis in breast cancers. Methods: Clinical data from 237 breast cancer patients who received neoadjuvant chemotherapy between 2012 and 2014 were reviewed. Correlations were sought between pCR and estrogen receptor (ER), progesterone receptor (PR), and HER2 status; Nottingham and nuclear grades; tumor tubule formation; mitotic score; Ki67 index; and tumoral and stromal lymphocytic infiltration (TLI and SLI, respectively). Results: Of the 237 cases, 104 (43.9%) achieved pCR. The HER2+ and triple negative breast cancer (TNBC) subtypes had higher pCR rates compared with the luminal subtype (ER+ or PR+ and HER2–). ER and PR negativity, HER2 positivity, Nottingham grade 3, increased TLI and SLI, high mitotic count and Ki67 score correlated significantly with pCR in the overall cohort. TLI and SLI correlated significantly with pCR in the HER2+ and TNBC subtypes in multivariate analysis, whereas no biomarkers correlated with pCR in the luminal subtype. Conclusions: In addition to the pathologic parameters and biomarkers already routinely assessed, evaluation of TLI and SLI may help to better select patients with HER2+ and TNBC for neoadjuvant chemotherapy." @default.
- W2420462095 created "2016-06-24" @default.
- W2420462095 creator A5001840708 @default.
- W2420462095 creator A5016403602 @default.
- W2420462095 creator A5019846100 @default.
- W2420462095 creator A5029560641 @default.
- W2420462095 creator A5031181272 @default.
- W2420462095 creator A5076163996 @default.
- W2420462095 creator A5079638534 @default.
- W2420462095 date "2016-06-01" @default.
- W2420462095 modified "2023-10-16" @default.
- W2420462095 title "Biomarkers Predicting Pathologic Complete Response to Neoadjuvant Chemotherapy in Breast Cancer" @default.
- W2420462095 cites W1965816054 @default.
- W2420462095 cites W1966804628 @default.
- W2420462095 cites W1967076728 @default.
- W2420462095 cites W1979832413 @default.
- W2420462095 cites W1987172318 @default.
- W2420462095 cites W1987326983 @default.
- W2420462095 cites W1992234802 @default.
- W2420462095 cites W2006816753 @default.
- W2420462095 cites W2019168823 @default.
- W2420462095 cites W2040239837 @default.
- W2420462095 cites W2042810218 @default.
- W2420462095 cites W2050645138 @default.
- W2420462095 cites W2053074390 @default.
- W2420462095 cites W2053662475 @default.
- W2420462095 cites W2055498399 @default.
- W2420462095 cites W2081177143 @default.
- W2420462095 cites W2094718541 @default.
- W2420462095 cites W2095865154 @default.
- W2420462095 cites W2099005045 @default.
- W2420462095 cites W2104337757 @default.
- W2420462095 cites W2109738158 @default.
- W2420462095 cites W2113165839 @default.
- W2420462095 cites W2114264989 @default.
- W2420462095 cites W2117984780 @default.
- W2420462095 cites W2118605519 @default.
- W2420462095 cites W2134539328 @default.
- W2420462095 cites W2147415463 @default.
- W2420462095 cites W2147638458 @default.
- W2420462095 cites W2157058802 @default.
- W2420462095 cites W2157285286 @default.
- W2420462095 cites W2159274850 @default.
- W2420462095 cites W2159640574 @default.
- W2420462095 cites W2165047644 @default.
- W2420462095 cites W2170469857 @default.
- W2420462095 cites W2291500685 @default.
- W2420462095 cites W2316247073 @default.
- W2420462095 doi "https://doi.org/10.1093/ajcp/aqw045" @default.
- W2420462095 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27298399" @default.
- W2420462095 hasPublicationYear "2016" @default.
- W2420462095 type Work @default.
- W2420462095 sameAs 2420462095 @default.
- W2420462095 citedByCount "61" @default.
- W2420462095 countsByYear W24204620952016 @default.
- W2420462095 countsByYear W24204620952017 @default.
- W2420462095 countsByYear W24204620952018 @default.
- W2420462095 countsByYear W24204620952019 @default.
- W2420462095 countsByYear W24204620952020 @default.
- W2420462095 countsByYear W24204620952021 @default.
- W2420462095 countsByYear W24204620952022 @default.
- W2420462095 countsByYear W24204620952023 @default.
- W2420462095 crossrefType "journal-article" @default.
- W2420462095 hasAuthorship W2420462095A5001840708 @default.
- W2420462095 hasAuthorship W2420462095A5016403602 @default.
- W2420462095 hasAuthorship W2420462095A5019846100 @default.
- W2420462095 hasAuthorship W2420462095A5029560641 @default.
- W2420462095 hasAuthorship W2420462095A5031181272 @default.
- W2420462095 hasAuthorship W2420462095A5076163996 @default.
- W2420462095 hasAuthorship W2420462095A5079638534 @default.
- W2420462095 hasBestOaLocation W24204620951 @default.
- W2420462095 hasConcept C121608353 @default.
- W2420462095 hasConcept C126322002 @default.
- W2420462095 hasConcept C142724271 @default.
- W2420462095 hasConcept C143998085 @default.
- W2420462095 hasConcept C2776694085 @default.
- W2420462095 hasConcept C2778292576 @default.
- W2420462095 hasConcept C2780110267 @default.
- W2420462095 hasConcept C530470458 @default.
- W2420462095 hasConcept C71924100 @default.
- W2420462095 hasConcept C84606932 @default.
- W2420462095 hasConceptScore W2420462095C121608353 @default.
- W2420462095 hasConceptScore W2420462095C126322002 @default.
- W2420462095 hasConceptScore W2420462095C142724271 @default.
- W2420462095 hasConceptScore W2420462095C143998085 @default.
- W2420462095 hasConceptScore W2420462095C2776694085 @default.
- W2420462095 hasConceptScore W2420462095C2778292576 @default.
- W2420462095 hasConceptScore W2420462095C2780110267 @default.
- W2420462095 hasConceptScore W2420462095C530470458 @default.
- W2420462095 hasConceptScore W2420462095C71924100 @default.
- W2420462095 hasConceptScore W2420462095C84606932 @default.
- W2420462095 hasIssue "6" @default.
- W2420462095 hasLocation W24204620951 @default.
- W2420462095 hasLocation W24204620952 @default.
- W2420462095 hasOpenAccess W2420462095 @default.
- W2420462095 hasPrimaryLocation W24204620951 @default.
- W2420462095 hasRelatedWork W1986496754 @default.
- W2420462095 hasRelatedWork W2064898491 @default.