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• W2420508780 abstract "In this paper an account is given of iso-antibodies which will allow four red cell antigen-a,ntibody systems to be identified in the rabbit. Three of these appear to form an allelomorphic series, the fourth seems to be inherited independently. This work developed out of an investigation in which an attempt was made to produce haemolytic disease of the newborn in the rabbit experimentally (Heard, Hinde & Mynors, 1949). All the serological characteristics of the human disease could be reproduced, but the baby rabbits remained well. This experiment was first made as long ago as 1933 by Keeler & Castle, who proved that while maternal antibody could pass from the mother to the foetus, the baby rabbits suffered no ill effects and must have 'neutralized' the antibody. In 1948 we used an adaptation of the antiglobulin direct sensitization test (Coombs, Mourant & Racea 1946), and by this means could demonstrate that though the baby rabbit did not appear ill? maternal iso-antibody was affixed to its red cells. Although the rabbit may not be very useful in the study of haemolytic disease of the newborn, the injection of red cell iso-antibody into newborn rabbits made them anaemic and jaundiced and the antibody could be demonstrated attached to their red cells. The signs and symptoms shown by the baby rabbits varied with the dose of antibody injected. The difEerence between rabbits which ha.d large doses of incompatible serum given parenterally and were sick, and well rabbits in which the antibody reached the red cells by naUtural channels, may have been one of dosage; had the dose of antibody been larger these rabbits might have been sick too: as were those described by Kellner & Hedal (1953b). However, the factors determining the amount of antibody on the rabbit's red cell are probably rather complicated. In another paper (Heard, 1955) it is shown that the cells of some rabbits absorb more homologous antibody than others, and that this may be due to a variation in the number of antigen sites available. The amount of antibody which red cells will absorb from a serum will depend on their own absorptive power and on the amount of antibody in the serum. In this paper four immune rabbit iso-antisera each containing a single antibody are described. No study has been made of naturally occurring iso-antibodies, which are found in the rabbit but are weak and relatively rare. An iso-agglutinin found in the serum of a female adult rabbit, which has never been inoculated with rabbit blood, may be not one of the weak, rather rare iso-agglutinins analagous to the naturally occurring human anti-A and anti-B agglutinins, but an immune antibody formed as a result of iso-immunization of pregnancy. In the author's experience this is uncommon. In one such case the red cells of a litter of apparently" @default.
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• W2420508780 date "2016-01-01" @default.
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• W2420508780 title "'1't1E RECOGNITION OF FOUR RED CEjrjTJ ANTIGEN- ANTIBODY SYSTEMS IN THE RABBIT" @default.
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