Matches in SemOpenAlex for { <https://semopenalex.org/work/W2420655857> ?p ?o ?g. }
- W2420655857 endingPage "516" @default.
- W2420655857 startingPage "508" @default.
- W2420655857 abstract "Emerging evidence suggests the nervous system, including the circadian timing system, influences susceptibility to osteoarthritis (OA) via direct and indirect effects. This Review describes the interactions between the brain and the joints in the context of OA, ageing, obesity and inflammation, and outlines therapeutic and research opportunities in this field. Osteoarthritis (OA) is a prevalent and debilitating joint disease for which ageing, obesity and chronic inflammation are known risk factors. The central, peripheral and autonomic nervous systems are essential in all metabolic systems, and emerging evidence suggests a role for these systems in OA. In the past few years, metabolic diseases, such as obesity or diabetes, have been linked to disruption of circadian rhythms that are tightly regulated by the nervous system, whereas inflammatory and autoimmune diseases are known to be linked to disruption of the cholinergic vagus nerve reflex. Interestingly, metabolism, inflammation and circadian rhythms have all been linked to the development and progression of OA. This article reviews current knowledge of the direct and indirect roles of the nervous system and circadian system in the initiation and/or progression of OA, and highlights the directions for future research in this emerging field." @default.
- W2420655857 created "2016-06-24" @default.
- W2420655857 creator A5042787588 @default.
- W2420655857 creator A5085771274 @default.
- W2420655857 date "2016-06-16" @default.
- W2420655857 modified "2023-10-17" @default.
- W2420655857 title "The brain–joint axis in osteoarthritis: nerves, circadian clocks and beyond" @default.
- W2420655857 cites W1550534049 @default.
- W2420655857 cites W1558908536 @default.
- W2420655857 cites W1574467103 @default.
- W2420655857 cites W1964927671 @default.
- W2420655857 cites W1966527137 @default.
- W2420655857 cites W1966888621 @default.
- W2420655857 cites W1968890500 @default.
- W2420655857 cites W1970214664 @default.
- W2420655857 cites W1970373291 @default.
- W2420655857 cites W1974219409 @default.
- W2420655857 cites W1976540475 @default.
- W2420655857 cites W1980685856 @default.
- W2420655857 cites W1982218488 @default.
- W2420655857 cites W1982708871 @default.
- W2420655857 cites W1983291196 @default.
- W2420655857 cites W1984912966 @default.
- W2420655857 cites W1986932792 @default.
- W2420655857 cites W1987699071 @default.
- W2420655857 cites W1989877233 @default.
- W2420655857 cites W1990356462 @default.
- W2420655857 cites W1994994441 @default.
- W2420655857 cites W1997151200 @default.
- W2420655857 cites W1999459848 @default.
- W2420655857 cites W2002797282 @default.
- W2420655857 cites W2003722956 @default.
- W2420655857 cites W2005229523 @default.
- W2420655857 cites W2005372213 @default.
- W2420655857 cites W2007247773 @default.
- W2420655857 cites W2007282158 @default.
- W2420655857 cites W2011804823 @default.
- W2420655857 cites W2012827104 @default.
- W2420655857 cites W2014313900 @default.
- W2420655857 cites W2016217879 @default.
- W2420655857 cites W2018125997 @default.
- W2420655857 cites W2018424479 @default.
- W2420655857 cites W2025243746 @default.
- W2420655857 cites W2025545117 @default.
- W2420655857 cites W2025745234 @default.
- W2420655857 cites W2026123588 @default.
- W2420655857 cites W2027831505 @default.
- W2420655857 cites W2031923163 @default.
- W2420655857 cites W2033417409 @default.
- W2420655857 cites W2033565755 @default.
- W2420655857 cites W2037252802 @default.
- W2420655857 cites W2038223171 @default.
- W2420655857 cites W2042500733 @default.
- W2420655857 cites W2047213275 @default.
- W2420655857 cites W2048241238 @default.
- W2420655857 cites W2048457027 @default.
- W2420655857 cites W2059438747 @default.
- W2420655857 cites W2060925737 @default.
- W2420655857 cites W2061768724 @default.
- W2420655857 cites W2063946784 @default.
- W2420655857 cites W2065119655 @default.
- W2420655857 cites W2065247475 @default.
- W2420655857 cites W2065529690 @default.
- W2420655857 cites W2069085724 @default.
- W2420655857 cites W2069742753 @default.
- W2420655857 cites W2070596698 @default.
- W2420655857 cites W2071013783 @default.
- W2420655857 cites W2071346451 @default.
- W2420655857 cites W2072416063 @default.
- W2420655857 cites W2079298940 @default.
- W2420655857 cites W2082734607 @default.
- W2420655857 cites W2083101144 @default.
- W2420655857 cites W2083279848 @default.
- W2420655857 cites W2085687131 @default.
- W2420655857 cites W2087788665 @default.
- W2420655857 cites W2087853338 @default.
- W2420655857 cites W2089056356 @default.
- W2420655857 cites W2091557482 @default.
- W2420655857 cites W2094025049 @default.
- W2420655857 cites W2100322905 @default.
- W2420655857 cites W2100607269 @default.
- W2420655857 cites W2103026809 @default.
- W2420655857 cites W2108014352 @default.
- W2420655857 cites W2108344016 @default.
- W2420655857 cites W2109643962 @default.
- W2420655857 cites W2110052568 @default.
- W2420655857 cites W2110994317 @default.
- W2420655857 cites W2111331057 @default.
- W2420655857 cites W2116688715 @default.
- W2420655857 cites W2116753388 @default.
- W2420655857 cites W2117121624 @default.
- W2420655857 cites W2126529900 @default.
- W2420655857 cites W2130213653 @default.
- W2420655857 cites W2131626977 @default.
- W2420655857 cites W2133918896 @default.
- W2420655857 cites W2134697369 @default.
- W2420655857 cites W2134734149 @default.
- W2420655857 cites W2134905207 @default.