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- W2420660304 abstract "Cyclosporin has had a major impact on organ transplantation, but associated nephrotoxicity is a significant problem. Renal hypothermia, a known anti-ischemic maneuver, limits cyclosporin-ischemic renal failure. Pharmacological manipulation with an anti-ischemic agent, such as trimetazidine, may prevent cyclosporin nephrotoxicity. We tested this hypothesis in a canine single kidney model of cyclosporin-enhanced ischemic renal failure. Trimetazidine treatment was associated with significantly better biochemical and histological markers of renal function and structure. Trimetazidine may have a role to play in protecting against cyclosporin nephrotoxicity in clinical renal transplantation." @default.
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- W2420660304 date "1993-04-01" @default.
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- W2420660304 title "Pharmacological Manipulation of Acute Cyclosporin Ischemic Renal Injury with Trimetazidine" @default.
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- W2420660304 doi "https://doi.org/10.1016/s0022-5347(17)36258-4" @default.
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