FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2420714045> ?p ?o ?g. }

• W2420714045 endingPage "C188" @default.
• W2420714045 startingPage "C179" @default.
• W2420714045 abstract "Hydrogen peroxide (H2O2) may incite cardiac ischemia-reperfusion injury. We evaluate herein the influence of H2O2-induced oxidative stress on heart muscle hexose metabolism in cultured neonatal rat cardiomyocytes, which have a substrate preference for carbohydrate. Cardiomyocyte exposure to 50 microM-1.0 mM bolus H2O2 transiently activated the pentose phosphate cycle and thereafter inhibited cellular glucose oxidation and glycolysis. These metabolic derangements were nonperoxidative in nature (as assessed in alpha-tocopherol-loaded cells) and occurred without acute change in cardiomyocyte hexose transport or glucose/glycogen reserves. Glycolytic inhibition was supported by the rapid, specific inactivation of glyceraldehyde-3-phosphate dehydrogenase (GAPDH). The degree of GAPDH inhibition correlated directly with the magnitude of the oxidative insult and was independent of both metal-catalyzed H2O2 reduction to free radicals and lipid peroxidation. Severe GAPDH inhibition was required for a rate-limiting effect on glycolytic flux. Cardiomyocyte pyruvate dehydrogenase was also inhibited by H2O2 overload, but to a lesser degree than GAPDH such that entry of hexose-derived acetyl units into the tricarboxylic acid cycle was not as restrictive as GAPDH inactivation to glycolytic ATP production. An increase in phosphofructokinase activity accompanied GAPDH inactivation, leading to the production and accumulation of glycolytic sugar phosphates at the expense of ATP equivalents. Cardiomyocyte treatment with iodoacetate or 2-deoxyglucose indicated that GAPDH inactivation/glycolytic blockade could account for approximately 50% of the maximal ATP loss following H2O2 overload. Partial restoration of GAPDH activity after a brief H2O2 pulse afforded some ATP recovery. These data establish that specific aspects of heart muscle hexose catabolism are H2O2-sensitive injury targets. The biochemical pathology of H2O2 overload on cardiomyocyte carbohydrate metabolism has implications for post-ischemic cardiac bioenergetics and function." @default.
• W2420714045 created "2016-06-24" @default.
• W2420714045 creator A5039688042 @default.
• W2420714045 creator A5041745171 @default.
• W2420714045 creator A5045369109 @default.
• W2420714045 date "1994-01-01" @default.
• W2420714045 modified "2023-10-16" @default.
• W2420714045 title "Hydroperoxide-induced oxidative stress impairs heart muscle cell carbohydrate metabolism" @default.
• W2420714045 cites W1556814137 @default.
• W2420714045 cites W1572582386 @default.
• W2420714045 cites W1970199917 @default.
• W2420714045 cites W1972821622 @default.
• W2420714045 cites W1975331470 @default.
• W2420714045 cites W1990465549 @default.
• W2420714045 cites W1997926976 @default.
• W2420714045 cites W2005201814 @default.
• W2420714045 cites W2006527424 @default.
• W2420714045 cites W2006554180 @default.
• W2420714045 cites W2017190537 @default.
• W2420714045 cites W2024336574 @default.
• W2420714045 cites W2035784351 @default.
• W2420714045 cites W2039979539 @default.
• W2420714045 cites W2048822577 @default.
• W2420714045 cites W2055693692 @default.
• W2420714045 cites W2062141382 @default.
• W2420714045 cites W2067451458 @default.
• W2420714045 cites W2069704785 @default.
• W2420714045 cites W2095359498 @default.
• W2420714045 cites W2121380625 @default.
• W2420714045 cites W2135387911 @default.
• W2420714045 cites W2148728357 @default.
• W2420714045 cites W2396555562 @default.
• W2420714045 cites W54700548 @default.
• W2420714045 doi "https://doi.org/10.1152/ajpcell.1994.266.1.c179" @default.
• W2420714045 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8304415" @default.
• W2420714045 hasPublicationYear "1994" @default.
• W2420714045 type Work @default.
• W2420714045 sameAs 2420714045 @default.
• W2420714045 citedByCount "115" @default.
• W2420714045 countsByYear W24207140452012 @default.
• W2420714045 countsByYear W24207140452013 @default.
• W2420714045 countsByYear W24207140452014 @default.
• W2420714045 countsByYear W24207140452015 @default.
• W2420714045 countsByYear W24207140452016 @default.
• W2420714045 countsByYear W24207140452018 @default.
• W2420714045 countsByYear W24207140452019 @default.
• W2420714045 countsByYear W24207140452021 @default.
• W2420714045 countsByYear W24207140452022 @default.
• W2420714045 countsByYear W24207140452023 @default.
• W2420714045 crossrefType "journal-article" @default.
• W2420714045 hasAuthorship W2420714045A5039688042 @default.
• W2420714045 hasAuthorship W2420714045A5041745171 @default.
• W2420714045 hasAuthorship W2420714045A5045369109 @default.
• W2420714045 hasConcept C134792803 @default.
• W2420714045 hasConcept C181199279 @default.
• W2420714045 hasConcept C185592680 @default.
• W2420714045 hasConcept C20251656 @default.
• W2420714045 hasConcept C2776151105 @default.
• W2420714045 hasConcept C2776317432 @default.
• W2420714045 hasConcept C2776393687 @default.
• W2420714045 hasConcept C2777499176 @default.
• W2420714045 hasConcept C2781272698 @default.
• W2420714045 hasConcept C3409486 @default.
• W2420714045 hasConcept C55493867 @default.
• W2420714045 hasConcept C57600042 @default.
• W2420714045 hasConcept C62231903 @default.
• W2420714045 hasConcept C86803240 @default.
• W2420714045 hasConcept C91754966 @default.
• W2420714045 hasConceptScore W2420714045C134792803 @default.
• W2420714045 hasConceptScore W2420714045C181199279 @default.
• W2420714045 hasConceptScore W2420714045C185592680 @default.
• W2420714045 hasConceptScore W2420714045C20251656 @default.
• W2420714045 hasConceptScore W2420714045C2776151105 @default.
• W2420714045 hasConceptScore W2420714045C2776317432 @default.
• W2420714045 hasConceptScore W2420714045C2776393687 @default.
• W2420714045 hasConceptScore W2420714045C2777499176 @default.
• W2420714045 hasConceptScore W2420714045C2781272698 @default.
• W2420714045 hasConceptScore W2420714045C3409486 @default.
• W2420714045 hasConceptScore W2420714045C55493867 @default.
• W2420714045 hasConceptScore W2420714045C57600042 @default.
• W2420714045 hasConceptScore W2420714045C62231903 @default.
• W2420714045 hasConceptScore W2420714045C86803240 @default.
• W2420714045 hasConceptScore W2420714045C91754966 @default.
• W2420714045 hasIssue "1" @default.
• W2420714045 hasLocation W24207140451 @default.
• W2420714045 hasLocation W24207140452 @default.
• W2420714045 hasOpenAccess W2420714045 @default.
• W2420714045 hasPrimaryLocation W24207140451 @default.
• W2420714045 hasRelatedWork W1889363392 @default.
• W2420714045 hasRelatedWork W1988064189 @default.
• W2420714045 hasRelatedWork W2160219722 @default.
• W2420714045 hasRelatedWork W2207463256 @default.
• W2420714045 hasRelatedWork W2400403112 @default.
• W2420714045 hasRelatedWork W2417846674 @default.
• W2420714045 hasRelatedWork W2420714045 @default.
• W2420714045 hasRelatedWork W2750359617 @default.
• W2420714045 hasRelatedWork W2988787281 @default.
• W2420714045 hasRelatedWork W35790772 @default.

• next