Matches in SemOpenAlex for { <https://semopenalex.org/work/W2420824370> ?p ?o ?g. }
- W2420824370 abstract "Natural compounds derived from medicinal plants have long been considered a rich source of novel therapeutic agents. Baicalin (Ba) is a bioactive flavonoid compound derived from the root of Scutellaria baicalensis, an herb widely used in traditional medicine for the treatment of various inflammatory diseases. In this study, we investigate the effects and mechanism of action of Ba in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). Ba treatment effectively ameliorated clinical disease severity in myelin oligodendrocyte glycoprotein (MOG)35-55 peptide-induced EAE, and reduced inflammation and demyelination of the central nervous system (CNS). Ba reduced infiltration of immune cells into the CNS, inhibited expression of proinflammatory molecules and chemokines, and prevented Th1 and Th17 cell differentiation via STAT/NFκB signaling pathways. Further, we showed that SOCS3 induction is essential to the effects of Ba, given that the inhibitory effect of Ba on pathogenic Th17 responses was largely abolished when SOCS3 signaling was knocked down. Taken together, our findings demonstrate that Ba has significant potential as a novel anti-inflammatory agent for therapy of autoimmune diseases such as MS." @default.
- W2420824370 created "2016-06-24" @default.
- W2420824370 creator A5008925941 @default.
- W2420824370 creator A5027616795 @default.
- W2420824370 creator A5029904155 @default.
- W2420824370 creator A5031836301 @default.
- W2420824370 creator A5038393529 @default.
- W2420824370 creator A5039932059 @default.
- W2420824370 creator A5070235745 @default.
- W2420824370 date "2015-11-30" @default.
- W2420824370 modified "2023-10-04" @default.
- W2420824370 title "Therapeutic effect of baicalin on experimental autoimmune encephalomyelitis is mediated by SOCS3 regulatory pathway" @default.
- W2420824370 cites W1535842809 @default.
- W2420824370 cites W1903126334 @default.
- W2420824370 cites W1939125543 @default.
- W2420824370 cites W194220377 @default.
- W2420824370 cites W1963993567 @default.
- W2420824370 cites W1965683282 @default.
- W2420824370 cites W1975588465 @default.
- W2420824370 cites W1975804755 @default.
- W2420824370 cites W1980386568 @default.
- W2420824370 cites W1985664608 @default.
- W2420824370 cites W1999768705 @default.
- W2420824370 cites W2006629206 @default.
- W2420824370 cites W2022559217 @default.
- W2420824370 cites W2024405339 @default.
- W2420824370 cites W2031472162 @default.
- W2420824370 cites W2034363206 @default.
- W2420824370 cites W2038249890 @default.
- W2420824370 cites W2039843867 @default.
- W2420824370 cites W2042021668 @default.
- W2420824370 cites W2044447793 @default.
- W2420824370 cites W2048948729 @default.
- W2420824370 cites W2054145339 @default.
- W2420824370 cites W2054254705 @default.
- W2420824370 cites W2060610804 @default.
- W2420824370 cites W2081347853 @default.
- W2420824370 cites W2084060787 @default.
- W2420824370 cites W2084388036 @default.
- W2420824370 cites W2085316561 @default.
- W2420824370 cites W2086264253 @default.
- W2420824370 cites W2091366403 @default.
- W2420824370 cites W2096638040 @default.
- W2420824370 cites W2099166441 @default.
- W2420824370 cites W2101365364 @default.
- W2420824370 cites W2102478991 @default.
- W2420824370 cites W2117645663 @default.
- W2420824370 cites W2121971093 @default.
- W2420824370 cites W2124233214 @default.
- W2420824370 cites W2125379328 @default.
- W2420824370 cites W2125961014 @default.
- W2420824370 cites W2131923232 @default.
- W2420824370 cites W2135200424 @default.
- W2420824370 cites W2138722443 @default.
- W2420824370 cites W2143541289 @default.
- W2420824370 cites W2145696691 @default.
- W2420824370 cites W2146470803 @default.
- W2420824370 cites W2153627006 @default.
- W2420824370 cites W2155013311 @default.
- W2420824370 cites W2170098900 @default.
- W2420824370 cites W2215197314 @default.
- W2420824370 cites W2336320822 @default.
- W2420824370 cites W2374101710 @default.
- W2420824370 cites W2555467323 @default.
- W2420824370 doi "https://doi.org/10.1038/srep17407" @default.
- W2420824370 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4663791" @default.
- W2420824370 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26616302" @default.
- W2420824370 hasPublicationYear "2015" @default.
- W2420824370 type Work @default.
- W2420824370 sameAs 2420824370 @default.
- W2420824370 citedByCount "70" @default.
- W2420824370 countsByYear W24208243702016 @default.
- W2420824370 countsByYear W24208243702017 @default.
- W2420824370 countsByYear W24208243702018 @default.
- W2420824370 countsByYear W24208243702019 @default.
- W2420824370 countsByYear W24208243702020 @default.
- W2420824370 countsByYear W24208243702021 @default.
- W2420824370 countsByYear W24208243702022 @default.
- W2420824370 countsByYear W24208243702023 @default.
- W2420824370 crossrefType "journal-article" @default.
- W2420824370 hasAuthorship W2420824370A5008925941 @default.
- W2420824370 hasAuthorship W2420824370A5027616795 @default.
- W2420824370 hasAuthorship W2420824370A5029904155 @default.
- W2420824370 hasAuthorship W2420824370A5031836301 @default.
- W2420824370 hasAuthorship W2420824370A5038393529 @default.
- W2420824370 hasAuthorship W2420824370A5039932059 @default.
- W2420824370 hasAuthorship W2420824370A5070235745 @default.
- W2420824370 hasBestOaLocation W24208243701 @default.
- W2420824370 hasConcept C126042315 @default.
- W2420824370 hasConcept C13373296 @default.
- W2420824370 hasConcept C142724271 @default.
- W2420824370 hasConcept C164027704 @default.
- W2420824370 hasConcept C188947578 @default.
- W2420824370 hasConcept C203014093 @default.
- W2420824370 hasConcept C204787440 @default.
- W2420824370 hasConcept C2776914184 @default.
- W2420824370 hasConcept C2777899865 @default.
- W2420824370 hasConcept C2778153525 @default.
- W2420824370 hasConcept C2778486448 @default.
- W2420824370 hasConcept C2778923194 @default.