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• W2420899029 abstract "The crystalline lens plays an important role in the refractive vision of vertebrates by facilitating variable fine focusing of light onto the retina. Loss of lens transparency, or cataract, is a frequently acquired cause of visual impairment in adults and may also present during childhood. Genetic studies have identified mutations in over 30 causative genes for congenital or other early-onset forms of cataract as well as several gene variants associated with age-related cataract. However, the pathogenic mechanisms resulting from genetic determinants of cataract are only just beginning to be understood. Here, we briefly summarize current concepts pointing to differences in the molecular mechanisms underlying congenital and age-related forms of cataract." @default.
• W2420899029 created "2016-06-24" @default.
• W2420899029 creator A5024630093 @default.
• W2420899029 creator A5091699331 @default.
• W2420899029 date "2017-03-01" @default.
• W2420899029 modified "2023-10-16" @default.
• W2420899029 title "Mutations and mechanisms in congenital and age-related cataracts" @default.
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• W2420899029 doi "https://doi.org/10.1016/j.exer.2016.06.011" @default.
• W2420899029 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5538314" @default.
• W2420899029 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27334249" @default.
• W2420899029 hasPublicationYear "2017" @default.
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