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- W2421008575 abstract "Abstract Hashimoto's encephalopathy is relapsing in nature showing a favorable response to treatment. Objectives To study clinical manifestations of patients presenting with encephalopathy, positive serum anti-TPO and their response to steroids. Method An observational cohort study in a tertiary health center (2013–2014). Workup included a detailed history, neurological examination, blood investigations, EEG, and CSF-study. Neuroimaging was done in patients of encephalopathy with positive serum anti-TPO. Pulse steroid was administered and the outcome was noted. Results Ten patients (7 males; 3 females) were included whose mean age was 59.2 years. Common clinical manifestations were cognitive impairment, behavioral abnormality, and altered sensorium. GTCS and myoclonic jerks were noted in 3 patients. Most patients were euthyroid. Serum anti-TPO was positive in all patients with a range of 72–1300 IU/L. EEG showed theta slowing and fronto-temporal slowing in 4 patients. Neuroimaging showed cerebral atrophy and white matter ischemic changes mostly. IV pulse steroid was given for 5 days in 7 out of 10 patients and repeated monthly in 3 patients. A good response was noted in 5 patients with relapse in two patients. Conclusion Hashimoto encephalopathy shows a variety of presentation but the presence of anti-TPO in serum and a good clinical response to steroid is what clinches its diagnosis." @default.
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- W2421008575 date "2016-04-01" @default.
- W2421008575 modified "2023-09-27" @default.
- W2421008575 title "Spectrum of Hashimoto's encephalopathy – An experience from the North East India" @default.
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- W2421008575 doi "https://doi.org/10.1016/j.injms.2016.05.001" @default.
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