Matches in SemOpenAlex for { <https://semopenalex.org/work/W2421130237> ?p ?o ?g. }
- W2421130237 startingPage "058669" @default.
- W2421130237 abstract "Hox genes are often clustered in animal genomes and exhibit spatial and/or temporal collinearity. It is generally believed that temporal collinearity is the major force preserving Hox clusters. However, studies combining genomic and gene expression analyses of Hox genes are scarce, particularly within Spiralia and Lophotrochozoa (e.g. mollusks, segmented worms, and flatworms). Here, we use two brachiopod species --Terebratalia transversa and Novocrania anomala-- that respectively belong to the two major brachiopod lineages to characterize their Hox complement, the presence of a Hox cluster, and the temporal and spatial expression of their Hox genes. We demonstrate that the Hox complement consists of ten Hox genes in T. transversa (lab, pb, Hox3, dfd, scr, lox5, antp, lox4, post2 and post1) and nine in N. anomala (missing post1). Additionally, T. transversa has an ordered, split Hox cluster. Expression analyses reveal that Hox genes are neither temporally nor spatially collinear, and only the genes pb (in T. transversa), Hox3 and dfd (in both brachiopods) show staggered expression in the mesoderm. Remarkably, lab, scr, antp and post1 are associated with the development of the chaetae and shell-forming epithelium, as also observed in annelid chaetae and mollusk shell fields. This, together with the expression of Arx homeobox, supports the deep conservation of the molecular basis for chaetae formation and shell patterning in Lophotrochozoa. Our findings challenge the current evolutionary scenario that (temporal) collinearity is the major mechanism preserving Hox clusters, and suggest that Hox genes were involved in the evolution of lophotrochozoan novelties." @default.
- W2421130237 created "2016-06-24" @default.
- W2421130237 creator A5006054858 @default.
- W2421130237 creator A5017859842 @default.
- W2421130237 creator A5022974740 @default.
- W2421130237 creator A5040128971 @default.
- W2421130237 creator A5046495620 @default.
- W2421130237 creator A5061933910 @default.
- W2421130237 date "2016-06-13" @default.
- W2421130237 modified "2023-09-28" @default.
- W2421130237 title "Brachiopods possess a split Hox cluster with signs of spatial, but not temporal collinearity" @default.
- W2421130237 cites W1494712239 @default.
- W2421130237 cites W1506451184 @default.
- W2421130237 cites W1537776120 @default.
- W2421130237 cites W1549886310 @default.
- W2421130237 cites W1550395484 @default.
- W2421130237 cites W1582956895 @default.
- W2421130237 cites W1625411518 @default.
- W2421130237 cites W1768482373 @default.
- W2421130237 cites W1821999370 @default.
- W2421130237 cites W1872270237 @default.
- W2421130237 cites W1897791091 @default.
- W2421130237 cites W1958031823 @default.
- W2421130237 cites W1965178844 @default.
- W2421130237 cites W1965369504 @default.
- W2421130237 cites W1968199051 @default.
- W2421130237 cites W1970413551 @default.
- W2421130237 cites W1975598767 @default.
- W2421130237 cites W1980204023 @default.
- W2421130237 cites W1982226598 @default.
- W2421130237 cites W1985348819 @default.
- W2421130237 cites W1986825968 @default.
- W2421130237 cites W1992134392 @default.
- W2421130237 cites W1999098357 @default.
- W2421130237 cites W2000947836 @default.
- W2421130237 cites W2002383724 @default.
- W2421130237 cites W2006788765 @default.
- W2421130237 cites W2006805292 @default.
- W2421130237 cites W2007696802 @default.
- W2421130237 cites W2009851083 @default.
- W2421130237 cites W2010575193 @default.
- W2421130237 cites W2011124999 @default.
- W2421130237 cites W2017838223 @default.
- W2421130237 cites W2023198782 @default.
- W2421130237 cites W2024371730 @default.
- W2421130237 cites W2026345779 @default.
- W2421130237 cites W2031112533 @default.
- W2421130237 cites W2033674704 @default.
- W2421130237 cites W2033690792 @default.
- W2421130237 cites W2035533511 @default.
- W2421130237 cites W2036897871 @default.
- W2421130237 cites W2038607448 @default.
- W2421130237 cites W2042869005 @default.
- W2421130237 cites W2043466269 @default.
- W2421130237 cites W2047517986 @default.
- W2421130237 cites W2052407549 @default.
- W2421130237 cites W2052926218 @default.
- W2421130237 cites W2056187821 @default.
- W2421130237 cites W2058016005 @default.
- W2421130237 cites W2062116795 @default.
- W2421130237 cites W2062140641 @default.
- W2421130237 cites W206241177 @default.
- W2421130237 cites W2062474573 @default.
- W2421130237 cites W2062540409 @default.
- W2421130237 cites W2067829962 @default.
- W2421130237 cites W2072818545 @default.
- W2421130237 cites W2073523429 @default.
- W2421130237 cites W2074051098 @default.
- W2421130237 cites W2075033992 @default.
- W2421130237 cites W2081696843 @default.
- W2421130237 cites W2085382357 @default.
- W2421130237 cites W2089306902 @default.
- W2421130237 cites W2095734894 @default.
- W2421130237 cites W2099103639 @default.
- W2421130237 cites W2105191441 @default.
- W2421130237 cites W2109009239 @default.
- W2421130237 cites W2111554513 @default.
- W2421130237 cites W2114866262 @default.
- W2421130237 cites W2120126956 @default.
- W2421130237 cites W2120892264 @default.
- W2421130237 cites W2121749968 @default.
- W2421130237 cites W2123447196 @default.
- W2421130237 cites W2126419817 @default.
- W2421130237 cites W2130530163 @default.
- W2421130237 cites W2130766330 @default.
- W2421130237 cites W2131271579 @default.
- W2421130237 cites W2131918846 @default.
- W2421130237 cites W2135271831 @default.
- W2421130237 cites W2136550480 @default.
- W2421130237 cites W2139134537 @default.
- W2421130237 cites W2141052558 @default.
- W2421130237 cites W2148377177 @default.
- W2421130237 cites W2150206293 @default.
- W2421130237 cites W2153646569 @default.
- W2421130237 cites W2159874421 @default.
- W2421130237 cites W2160378127 @default.
- W2421130237 cites W2166969664 @default.
- W2421130237 cites W2169210111 @default.
- W2421130237 cites W2217451949 @default.