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- W2421685414 abstract "The effect of inorganic, alkyl, aryl and other mercury compounds on the dorsal root ganglia from chick embryos in culture was studied in order to investigate the relationship between the structure of mercury compounds and the toxicity on the nervous tissue. The results obtained are as follows. 1. When chloride was introduced to the hydrophilic moiety of the mercury compounds instead of iodine, the compounds were found to be more toxic for the outgrowth of Schwann cells and nerve fibers. The binding of a hydrophobic group to the hydrophilic moiety of mercury compounds did not show the decrease in the toxicity. 2. The toxicity of mercury compounds was determined principally by the character of hydrophobic moiety. Phenyl mercury was less toxic than alkyl one. Alkyl mercury compounds having short carbon chains was more toxic than those having longer chains. 3. L-Cysteine hydrochloride, DL-penicillamine (DL-β-mercaptovaline), and BAL (2, 3-dimercaptopropanol) did not inhibit the toxic effect of organic mercury compounds. This results indicate that the mechanism of hydrophilic moiety could not be explained only by the binding of the moiety with SH group of the membranes or proteins. 4. Cholesterol, cholesterol palmitate, cephalin, and lecithin did not inhibit the toxic effect of organic mercury compounds. However, sphingomyelin and phosphatidyl-L-serine tended to improve the outgrowth of Schwann cells and nerve fibers in the presence of organic mercury compounds. These results suggest the specific binding of the hydrophobic moiety with the specific binding sites of the membrane. 5. The degree of the toxicity of the compounds having the multiple sizes of methyl mercury chloride was almost the same as that of methyl mercury chloride itself. This result seems to indicate the presence of the regular distribution of binding sites on the surface of the membrane. 6. It was pointed out that the tissue culture technique of the nervous system was useful to test chemicals from many industries to see whether they have neurotoxicity or not." @default.
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- W2421685414 date "1971-01-01" @default.
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- W2421685414 title "THE EFFECT OF VARIOUS MERCURY COMPOUNDS ON NERVOUS TISSUE IN CULTURE" @default.
- W2421685414 doi "https://doi.org/10.1539/joh1959.13.515" @default.
- W2421685414 hasPublicationYear "1971" @default.
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