FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2421692008> ?p ?o ?g. }

• W2421692008 endingPage "4056" @default.
• W2421692008 startingPage "4045" @default.
• W2421692008 abstract "Abstract Purpose: Male breast cancer is rare, and its genomic landscape has yet to be fully characterized. Lacking studies in men, treatment of males with breast cancer is extrapolated from results in females with breast cancer. We sought to define whether male breast cancers harbor somatic genetic alterations in genes frequently altered in female breast cancers. Experimental Design: All male breast cancers were estrogen receptor–positive, and all but two were HER2-negative. Fifty-nine male breast cancers were subtyped by immunohistochemistry, and tumor–normal pairs were microdissected and subjected to massively parallel sequencing targeting all exons of 241 genes frequently mutated in female breast cancers or DNA-repair related. The repertoires of somatic mutations and copy number alterations of male breast cancers were compared with that of subtype-matched female breast cancers. Results: Twenty-nine percent and 71% of male breast cancers were immunohistochemically classified as luminal A–like or luminal B–like, respectively. Male breast cancers displayed a heterogeneous repertoire of somatic genetic alterations that to some extent recapitulated that of estrogen receptor (ER)-positive/HER2-negative female breast cancers, including recurrent mutations affecting PIK3CA (20%) and GATA3 (15%). ER-positive/HER2-negative male breast cancers, however, less frequently harbored 16q losses, and PIK3CA and TP53 mutations than ER-positive/HER2-negative female breast cancers. In addition, male breast cancers were found to be significantly enriched for mutations affecting DNA repair–related genes. Conclusions: Male breast cancers less frequently harbor somatic genetic alterations typical of ER-positive/HER2-negative female breast cancers, such as PIK3CA and TP53 mutations and losses of 16q, suggesting that at least a subset of male breast cancers are driven by a distinct repertoire of somatic changes. Given the genomic differences, caution may be needed in the application of biologic and therapeutic findings from studies of female breast cancers to male breast cancers. Clin Cancer Res; 22(16); 4045–56. ©2016 AACR." @default.
• W2421692008 created "2016-06-24" @default.
• W2421692008 creator A5001209967 @default.
• W2421692008 creator A5001561973 @default.
• W2421692008 creator A5007310378 @default.
• W2421692008 creator A5016200153 @default.
• W2421692008 creator A5016638133 @default.
• W2421692008 creator A5017749409 @default.
• W2421692008 creator A5023182871 @default.
• W2421692008 creator A5025053302 @default.
• W2421692008 creator A5029040081 @default.
• W2421692008 creator A5031683228 @default.
• W2421692008 creator A5039225060 @default.
• W2421692008 creator A5040506127 @default.
• W2421692008 creator A5047713528 @default.
• W2421692008 creator A5051087530 @default.
• W2421692008 creator A5052303092 @default.
• W2421692008 creator A5057848295 @default.
• W2421692008 creator A5068030542 @default.
• W2421692008 creator A5076310424 @default.
• W2421692008 creator A5077235697 @default.
• W2421692008 creator A5080183722 @default.
• W2421692008 creator A5081742846 @default.
• W2421692008 creator A5089906802 @default.
• W2421692008 date "2016-08-14" @default.
• W2421692008 modified "2023-10-07" @default.
• W2421692008 title "The Genomic Landscape of Male Breast Cancers" @default.
• W2421692008 cites W1899376663 @default.
• W2421692008 cites W1997545849 @default.
• W2421692008 cites W2001790878 @default.
• W2421692008 cites W2002150942 @default.
• W2421692008 cites W2005895632 @default.
• W2421692008 cites W2009720434 @default.
• W2421692008 cites W2010406120 @default.
• W2421692008 cites W2010871781 @default.
• W2421692008 cites W2011418697 @default.
• W2421692008 cites W2014315300 @default.
• W2421692008 cites W2021341670 @default.
• W2421692008 cites W2022495797 @default.
• W2421692008 cites W2029944894 @default.
• W2421692008 cites W2044702943 @default.
• W2421692008 cites W2059079705 @default.
• W2421692008 cites W2062401605 @default.
• W2421692008 cites W2072572998 @default.
• W2421692008 cites W2076357933 @default.
• W2421692008 cites W2082790098 @default.
• W2421692008 cites W2089335658 @default.
• W2421692008 cites W2096283457 @default.
• W2421692008 cites W2097015349 @default.
• W2421692008 cites W2101677522 @default.
• W2421692008 cites W2101979288 @default.
• W2421692008 cites W2102140136 @default.
• W2421692008 cites W2103441770 @default.
• W2421692008 cites W2108771944 @default.
• W2421692008 cites W2114029728 @default.
• W2421692008 cites W2114031931 @default.
• W2421692008 cites W2117775530 @default.
• W2421692008 cites W2119048498 @default.
• W2421692008 cites W2123621576 @default.
• W2421692008 cites W2124659104 @default.
• W2421692008 cites W2130625546 @default.
• W2421692008 cites W2137853125 @default.
• W2421692008 cites W2138601221 @default.
• W2421692008 cites W2141204501 @default.
• W2421692008 cites W2141926802 @default.
• W2421692008 cites W2144957807 @default.
• W2421692008 cites W2146290346 @default.
• W2421692008 cites W2150134401 @default.
• W2421692008 cites W2151093629 @default.
• W2421692008 cites W2155943701 @default.
• W2421692008 cites W2161162779 @default.
• W2421692008 cites W2168133698 @default.
• W2421692008 cites W2170490448 @default.
• W2421692008 cites W2202954603 @default.
• W2421692008 cites W2405513305 @default.
• W2421692008 cites W2560367415 @default.
• W2421692008 cites W2593526662 @default.
• W2421692008 doi "https://doi.org/10.1158/1078-0432.ccr-15-2840" @default.
• W2421692008 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4987160" @default.
• W2421692008 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26960396" @default.
• W2421692008 hasPublicationYear "2016" @default.
• W2421692008 type Work @default.
• W2421692008 sameAs 2421692008 @default.
• W2421692008 citedByCount "108" @default.
• W2421692008 countsByYear W24216920082016 @default.
• W2421692008 countsByYear W24216920082017 @default.
• W2421692008 countsByYear W24216920082018 @default.
• W2421692008 countsByYear W24216920082019 @default.
• W2421692008 countsByYear W24216920082020 @default.
• W2421692008 countsByYear W24216920082021 @default.
• W2421692008 countsByYear W24216920082022 @default.
• W2421692008 countsByYear W24216920082023 @default.
• W2421692008 crossrefType "journal-article" @default.
• W2421692008 hasAuthorship W2421692008A5001209967 @default.
• W2421692008 hasAuthorship W2421692008A5001561973 @default.
• W2421692008 hasAuthorship W2421692008A5007310378 @default.
• W2421692008 hasAuthorship W2421692008A5016200153 @default.
• W2421692008 hasAuthorship W2421692008A5016638133 @default.

• next