Matches in SemOpenAlex for { <https://semopenalex.org/work/W2421787307> ?p ?o ?g. }
- W2421787307 endingPage "132" @default.
- W2421787307 startingPage "120" @default.
- W2421787307 abstract "Although epithelial NF-κB signaling is important for lung carcinogenesis, NF-κB inhibitors are ineffective for cancer treatment. To explain this paradox, we studied mice with genetic deletion of IKKβ in myeloid cells and found enhanced tumorigenesis in Kras(G12D) and urethane models of lung cancer. Myeloid-specific inhibition of NF-κB augmented pro-IL-1β processing by cathepsin G in neutrophils, leading to increased IL-1β and enhanced epithelial cell proliferation. Combined treatment with bortezomib, a proteasome inhibitor that blocks NF-κB activation, and IL-1 receptor antagonist reduced tumor formation and growth in vivo. In lung cancer patients, plasma IL-1β levels correlated with poor prognosis, and IL-1β increased following bortezomib treatment. Together, our studies elucidate an important role for neutrophils and IL-1β in lung carcinogenesis and resistance to NF-κB inhibitors." @default.
- W2421787307 created "2016-06-24" @default.
- W2421787307 creator A5001913247 @default.
- W2421787307 creator A5003270601 @default.
- W2421787307 creator A5007129518 @default.
- W2421787307 creator A5011724465 @default.
- W2421787307 creator A5012772335 @default.
- W2421787307 creator A5014481026 @default.
- W2421787307 creator A5049255907 @default.
- W2421787307 creator A5050712571 @default.
- W2421787307 creator A5056315342 @default.
- W2421787307 creator A5061398203 @default.
- W2421787307 creator A5063872240 @default.
- W2421787307 creator A5077410158 @default.
- W2421787307 creator A5085522616 @default.
- W2421787307 creator A5090645846 @default.
- W2421787307 date "2016-06-01" @default.
- W2421787307 modified "2023-10-14" @default.
- W2421787307 title "Neutrophil-Derived IL-1β Impairs the Efficacy of NF-κB Inhibitors against Lung Cancer" @default.
- W2421787307 cites W1486878670 @default.
- W2421787307 cites W1533217355 @default.
- W2421787307 cites W1581220495 @default.
- W2421787307 cites W1602437032 @default.
- W2421787307 cites W1696210500 @default.
- W2421787307 cites W1920787626 @default.
- W2421787307 cites W1971658408 @default.
- W2421787307 cites W1971762239 @default.
- W2421787307 cites W1982650056 @default.
- W2421787307 cites W1985538305 @default.
- W2421787307 cites W1990974592 @default.
- W2421787307 cites W1991493240 @default.
- W2421787307 cites W1992841021 @default.
- W2421787307 cites W1996563138 @default.
- W2421787307 cites W1999482469 @default.
- W2421787307 cites W2000196730 @default.
- W2421787307 cites W2002157461 @default.
- W2421787307 cites W2004150448 @default.
- W2421787307 cites W2007470751 @default.
- W2421787307 cites W2013743238 @default.
- W2421787307 cites W2018790754 @default.
- W2421787307 cites W2021276541 @default.
- W2421787307 cites W2022895499 @default.
- W2421787307 cites W2026760030 @default.
- W2421787307 cites W2038958404 @default.
- W2421787307 cites W2048111014 @default.
- W2421787307 cites W2048649566 @default.
- W2421787307 cites W2050389860 @default.
- W2421787307 cites W2100950834 @default.
- W2421787307 cites W2102450703 @default.
- W2421787307 cites W2105593208 @default.
- W2421787307 cites W2105724560 @default.
- W2421787307 cites W2110719738 @default.
- W2421787307 cites W2114063557 @default.
- W2421787307 cites W2121296674 @default.
- W2421787307 cites W2124076790 @default.
- W2421787307 cites W2125194042 @default.
- W2421787307 cites W2125867335 @default.
- W2421787307 cites W2136681413 @default.
- W2421787307 cites W2136951601 @default.
- W2421787307 cites W2143428408 @default.
- W2421787307 cites W2155360682 @default.
- W2421787307 cites W2156633409 @default.
- W2421787307 cites W2157778803 @default.
- W2421787307 cites W2316823859 @default.
- W2421787307 cites W2398348046 @default.
- W2421787307 cites W2783677708 @default.
- W2421787307 doi "https://doi.org/10.1016/j.celrep.2016.05.085" @default.
- W2421787307 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4927403" @default.
- W2421787307 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27320908" @default.
- W2421787307 hasPublicationYear "2016" @default.
- W2421787307 type Work @default.
- W2421787307 sameAs 2421787307 @default.
- W2421787307 citedByCount "74" @default.
- W2421787307 countsByYear W24217873072016 @default.
- W2421787307 countsByYear W24217873072017 @default.
- W2421787307 countsByYear W24217873072018 @default.
- W2421787307 countsByYear W24217873072019 @default.
- W2421787307 countsByYear W24217873072020 @default.
- W2421787307 countsByYear W24217873072021 @default.
- W2421787307 countsByYear W24217873072022 @default.
- W2421787307 countsByYear W24217873072023 @default.
- W2421787307 crossrefType "journal-article" @default.
- W2421787307 hasAuthorship W2421787307A5001913247 @default.
- W2421787307 hasAuthorship W2421787307A5003270601 @default.
- W2421787307 hasAuthorship W2421787307A5007129518 @default.
- W2421787307 hasAuthorship W2421787307A5011724465 @default.
- W2421787307 hasAuthorship W2421787307A5012772335 @default.
- W2421787307 hasAuthorship W2421787307A5014481026 @default.
- W2421787307 hasAuthorship W2421787307A5049255907 @default.
- W2421787307 hasAuthorship W2421787307A5050712571 @default.
- W2421787307 hasAuthorship W2421787307A5056315342 @default.
- W2421787307 hasAuthorship W2421787307A5061398203 @default.
- W2421787307 hasAuthorship W2421787307A5063872240 @default.
- W2421787307 hasAuthorship W2421787307A5077410158 @default.
- W2421787307 hasAuthorship W2421787307A5085522616 @default.
- W2421787307 hasAuthorship W2421787307A5090645846 @default.
- W2421787307 hasBestOaLocation W24217873071 @default.
- W2421787307 hasConcept C100175707 @default.