Matches in SemOpenAlex for { <https://semopenalex.org/work/W2422184525> ?p ?o ?g. }
- W2422184525 abstract "PAK1 inhibitors are known to markedly improve social and cognitive function in several animal models of brain disorders, including autism, but the underlying mechanisms remain elusive. We show here that disruption of PAK1 in mice suppresses inhibitory neurotransmission through an increase in tonic, but not phasic, secretion of endocannabinoids (eCB). Consistently, we found elevated levels of anandamide (AEA), but not 2-arachidonoylglycerol (2-AG) following PAK1 disruption. This increased tonic AEA signaling is mediated by reduced cyclooxygenase-2 (COX-2), and COX-2 inhibitors recapitulate the effect of PAK1 deletion on GABAergic transmission in a CB1 receptor-dependent manner. These results establish a novel signaling process whereby PAK1 upregulates COX-2, reduces AEA and restricts tonic eCB-mediated processes. Because PAK1 and eCB are both critically involved in many other organ systems in addition to the brain, our findings may provide a unified mechanism by which PAK1 regulates these systems and their dysfunctions including cancers, inflammations and allergies." @default.
- W2422184525 created "2016-06-24" @default.
- W2422184525 creator A5000015409 @default.
- W2422184525 creator A5008253319 @default.
- W2422184525 creator A5019248299 @default.
- W2422184525 creator A5025203510 @default.
- W2422184525 creator A5038525380 @default.
- W2422184525 creator A5044577761 @default.
- W2422184525 creator A5062830747 @default.
- W2422184525 creator A5065752454 @default.
- W2422184525 creator A5074736590 @default.
- W2422184525 creator A5081208871 @default.
- W2422184525 date "2016-06-14" @default.
- W2422184525 modified "2023-10-07" @default.
- W2422184525 title "p21-activated kinase 1 restricts tonic endocannabinoid signaling in the hippocampus" @default.
- W2422184525 cites W1485428340 @default.
- W2422184525 cites W1648442420 @default.
- W2422184525 cites W1674182966 @default.
- W2422184525 cites W1892287994 @default.
- W2422184525 cites W1963724713 @default.
- W2422184525 cites W1965336646 @default.
- W2422184525 cites W1974490587 @default.
- W2422184525 cites W1977206884 @default.
- W2422184525 cites W1979518536 @default.
- W2422184525 cites W1983673557 @default.
- W2422184525 cites W1994805165 @default.
- W2422184525 cites W1996056359 @default.
- W2422184525 cites W2006423839 @default.
- W2422184525 cites W2006926570 @default.
- W2422184525 cites W2015213948 @default.
- W2422184525 cites W2028363992 @default.
- W2422184525 cites W2029950812 @default.
- W2422184525 cites W2031694689 @default.
- W2422184525 cites W2040700439 @default.
- W2422184525 cites W2043033522 @default.
- W2422184525 cites W2049351028 @default.
- W2422184525 cites W2050322614 @default.
- W2422184525 cites W2057821563 @default.
- W2422184525 cites W2064919477 @default.
- W2422184525 cites W2066475196 @default.
- W2422184525 cites W2067677546 @default.
- W2422184525 cites W2070581367 @default.
- W2422184525 cites W2072652550 @default.
- W2422184525 cites W2078544102 @default.
- W2422184525 cites W2080649553 @default.
- W2422184525 cites W2082352870 @default.
- W2422184525 cites W2089912569 @default.
- W2422184525 cites W2090082293 @default.
- W2422184525 cites W2091053629 @default.
- W2422184525 cites W2118102282 @default.
- W2422184525 cites W2118625847 @default.
- W2422184525 cites W2120019053 @default.
- W2422184525 cites W2129277563 @default.
- W2422184525 cites W2129927715 @default.
- W2422184525 cites W2133748767 @default.
- W2422184525 cites W2138440781 @default.
- W2422184525 cites W2142679888 @default.
- W2422184525 cites W2146959320 @default.
- W2422184525 cites W2158593571 @default.
- W2422184525 cites W2161204141 @default.
- W2422184525 cites W2168499817 @default.
- W2422184525 cites W2257383498 @default.
- W2422184525 cites W2334244908 @default.
- W2422184525 cites W2419085364 @default.
- W2422184525 doi "https://doi.org/10.7554/elife.14653" @default.
- W2422184525 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4907698" @default.
- W2422184525 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27296803" @default.
- W2422184525 hasPublicationYear "2016" @default.
- W2422184525 type Work @default.
- W2422184525 sameAs 2422184525 @default.
- W2422184525 citedByCount "18" @default.
- W2422184525 countsByYear W24221845252016 @default.
- W2422184525 countsByYear W24221845252017 @default.
- W2422184525 countsByYear W24221845252018 @default.
- W2422184525 countsByYear W24221845252019 @default.
- W2422184525 countsByYear W24221845252020 @default.
- W2422184525 countsByYear W24221845252021 @default.
- W2422184525 countsByYear W24221845252022 @default.
- W2422184525 crossrefType "journal-article" @default.
- W2422184525 hasAuthorship W2422184525A5000015409 @default.
- W2422184525 hasAuthorship W2422184525A5008253319 @default.
- W2422184525 hasAuthorship W2422184525A5019248299 @default.
- W2422184525 hasAuthorship W2422184525A5025203510 @default.
- W2422184525 hasAuthorship W2422184525A5038525380 @default.
- W2422184525 hasAuthorship W2422184525A5044577761 @default.
- W2422184525 hasAuthorship W2422184525A5062830747 @default.
- W2422184525 hasAuthorship W2422184525A5065752454 @default.
- W2422184525 hasAuthorship W2422184525A5074736590 @default.
- W2422184525 hasAuthorship W2422184525A5081208871 @default.
- W2422184525 hasBestOaLocation W24221845251 @default.
- W2422184525 hasConcept C127573956 @default.
- W2422184525 hasConcept C135285700 @default.
- W2422184525 hasConcept C148001335 @default.
- W2422184525 hasConcept C169760540 @default.
- W2422184525 hasConcept C170493617 @default.
- W2422184525 hasConcept C17077164 @default.
- W2422184525 hasConcept C200170125 @default.
- W2422184525 hasConcept C24901178 @default.
- W2422184525 hasConcept C2778938600 @default.
- W2422184525 hasConcept C2779783865 @default.