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- W2422698599 abstract "Objective To test the effect of Levetiracetam(LEV) on the sodium currents of rat hippocampal neurons exposed to epileptogenic coriaria lactone(CL).Methods Acutely isolated Sprague-Dawley Rat hippocampal neurons were subjected to the whole-cell mode of patch clamp under experimental conditions designed to detect voltage-gated sodium currents.The CL(0.2 mg/mL) was used to increase the sodium currents of the neurons.Then the LEV was added(150 or 300 μmol/L) to test the effect of LEV on the peak current amplitudes through a comparison with the control group in which extracellular solution was added instead and the group in which nothing was added.Another group was pretreated with 300 μmol/L of LEV before the neutrons were treated with the CL.Results The maximum peak amplitudes(MPA) of the sodium currents increased 36.92%±2.84% by the 150 μmol/L of LEV(P0.05),similar to those exposed to the CL only(P0.05).The increase of MPA of the sodium currents by the 300 μmol/L of LEV(16.58%±1.56%) was less than those exposed to the CL only(P0.05).However,no significant difference was found between the 300 μmol/L LEV treated group and the control group(P0.05).The MPA of the sodium currents of LEV pretreated neutrons increased 32.86%±6.73% (P0.05),similar to those without pretreatment(P0.05).Conclusion The LEV does not decrease the sodium currents of rat hippocampal neurons induced by the CL.The antiepileptic action of LEV has nothing to do with the neuronal voltage-gated sodium channels." @default.
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- W2422698599 date "2007-09-01" @default.
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- W2422698599 title "Effect of levetiracetam on the sodium currents of rat hippocampal neurons exposed to coriaria lactone" @default.
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