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• W2422855778 endingPage "2462" @default.
• W2422855778 startingPage "2449" @default.
• W2422855778 abstract "ABSTRACT γ 9 δ 2 T cells provide a natural bridge between innate and adaptive immunity, rapidly and potently respond to pathogen infection in mucosal tissues, and are prominently induced by both tuberculosis (TB) infection and bacillus Calmette Guérin (BCG) vaccination. Mycobacterium-expanded γ 9 δ 2 T cells represent only a subset of the phosphoantigen {isopentenyl pyrophosphate [IPP] and ( E )-4-hydroxy-3-methyl-but-2-enylpyrophosphate [HMBPP]}-responsive γ 9 δ 2 T cells, expressing an oligoclonal set of T cell receptor (TCR) sequences which more efficiently recognize and inhibit intracellular Mycobacterium tuberculosis infection. Based on this premise, we have been searching for M. tuberculosis antigens specifically capable of inducing a unique subset of mycobacterium-protective γ 9 δ 2 T cells. Our screening strategy includes the identification of M. tuberculosis fractions that expand γ 9 δ 2 T cells with biological functions capable of inhibiting intracellular mycobacterial replication. Chemical treatments of M. tuberculosis whole-cell lysates (MtbWL) ruled out protein, nucleic acid, and nonpolar lipids as the M. tuberculosis antigens inducing protective γ 9 δ 2 T cells. Mild acid hydrolysis, which transforms complex carbohydrate to monomeric residues, abrogated the specific activity of M. tuberculosis whole-cell lysates, suggesting that a polysaccharide was required for biological activity. Extraction of MtbWL with chloroform-methanol-water (10:10:3) resulted in a polar lipid fraction with highly enriched specific activity; this activity was further enriched by silica gel chromatography. A combination of mass spectrometry and nuclear magnetic resonance analysis of bioactive fractions indicated that 6- O -methylglucose-containing lipopolysaccharides (mGLP) are predominant components present in this active fraction. These results have important implications for the development of new immunotherapeutic approaches for prevention and treatment of TB." @default.
• W2422855778 created "2016-06-24" @default.
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• W2422855778 date "2016-09-01" @default.
• W2422855778 modified "2023-10-16" @default.
• W2422855778 title "A Subset of Protective γ ₉ δ ₂ T Cells Is Activated by Novel Mycobacterial Glycolipid Components" @default.
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• W2422855778 cites W1544076059 @default.
• W2422855778 cites W1724974106 @default.
• W2422855778 cites W1785638896 @default.
• W2422855778 cites W1847568571 @default.
• W2422855778 cites W1855341754 @default.
• W2422855778 cites W1920987296 @default.
• W2422855778 cites W1968587304 @default.
• W2422855778 cites W1972120590 @default.
• W2422855778 cites W1978277750 @default.
• W2422855778 cites W1984968934 @default.
• W2422855778 cites W1987608235 @default.
• W2422855778 cites W1987818432 @default.
• W2422855778 cites W1992037894 @default.
• W2422855778 cites W1992794673 @default.
• W2422855778 cites W1994448362 @default.
• W2422855778 cites W1995254015 @default.
• W2422855778 cites W1995340360 @default.
• W2422855778 cites W2004690260 @default.
• W2422855778 cites W2013505681 @default.
• W2422855778 cites W2014275997 @default.
• W2422855778 cites W2015958044 @default.
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• W2422855778 cites W2017453418 @default.
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• W2422855778 cites W2035602962 @default.
• W2422855778 cites W2042814843 @default.
• W2422855778 cites W2047712420 @default.
• W2422855778 cites W2047944199 @default.
• W2422855778 cites W2053357559 @default.
• W2422855778 cites W2057140144 @default.
• W2422855778 cites W2060645697 @default.
• W2422855778 cites W2070779717 @default.
• W2422855778 cites W2073312795 @default.
• W2422855778 cites W2073334951 @default.
• W2422855778 cites W2076752937 @default.
• W2422855778 cites W2079821054 @default.
• W2422855778 cites W2080630809 @default.
• W2422855778 cites W2081750772 @default.
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• W2422855778 cites W2118107318 @default.
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• W2422855778 cites W2127367385 @default.
• W2422855778 cites W2133289974 @default.
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• W2422855778 doi "https://doi.org/10.1128/iai.01322-15" @default.
• W2422855778 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4995917" @default.
• W2422855778 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27297390" @default.
• W2422855778 hasPublicationYear "2016" @default.
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