Matches in SemOpenAlex for { <https://semopenalex.org/work/W2422906106> ?p ?o ?g. }
- W2422906106 endingPage "1143" @default.
- W2422906106 startingPage "1133" @default.
- W2422906106 abstract "Environmental contaminants from wastewater and industrial or agricultural areas are known to have adverse effects on development, reproduction, and metabolism. However, reliable assessment of environmental contaminant impact at low (i.e., ambient) concentrations using genomics and transcriptomics approaches has proven challenging. A goldfish model was used to investigate the effects of aquatic pollutant exposure in vivo by means of quantitative nuclear magnetic resonance metabolomics in multiple organs to elucidate a system-wide response. Animals were exposed to 4,4'-isopropylidenediphenol (Bisphenol-A, BPA), di-(2-ethylhexyl)-phthalate (DEHP), and nonylphenol (NP). Metabolite-specific spectral analysis combined with pathway-driven bioinformatics indicated changes in energy and lipid metabolism in liver following exposure to individual contaminants and a tertiary mixture. A dissimilar response in testis exposed to DEHP and mixture indicates disrupted AMPK and cAMP signaling. Uniquely, our observations (1) suggest that exposure to a contaminant mixture is characterized by a stress response not predicted from exposure to individual contaminants, even in the absence of other phenotypic features and (2) demonstrate the sensitivity of metabolomics in risk-assessment of environmental toxicant mixtures at ambient concentrations by detecting early stage metabolic dysregulation. These findings have general applicability in the assessment of benign compound mixtures in environmental and pharmaceutical development." @default.
- W2422906106 created "2016-06-24" @default.
- W2422906106 creator A5002421690 @default.
- W2422906106 creator A5004310617 @default.
- W2422906106 creator A5026909946 @default.
- W2422906106 creator A5026935265 @default.
- W2422906106 creator A5037483221 @default.
- W2422906106 date "2011-12-29" @default.
- W2422906106 modified "2023-09-27" @default.
- W2422906106 title "Environmental Contaminant Mixtures at Ambient Concentrations Invoke a Metabolic Stress Response in Goldfish Not Predicted from Exposure to Individual Compounds Alone" @default.
- W2422906106 cites W1516095885 @default.
- W2422906106 cites W1543950566 @default.
- W2422906106 cites W1965805017 @default.
- W2422906106 cites W1966854042 @default.
- W2422906106 cites W1967667217 @default.
- W2422906106 cites W1968182297 @default.
- W2422906106 cites W1973829843 @default.
- W2422906106 cites W1976381556 @default.
- W2422906106 cites W1976893340 @default.
- W2422906106 cites W1978619016 @default.
- W2422906106 cites W1982594558 @default.
- W2422906106 cites W1987538361 @default.
- W2422906106 cites W1990714989 @default.
- W2422906106 cites W1995192295 @default.
- W2422906106 cites W2005585150 @default.
- W2422906106 cites W2007975243 @default.
- W2422906106 cites W2015192043 @default.
- W2422906106 cites W2017918116 @default.
- W2422906106 cites W2018219757 @default.
- W2422906106 cites W2022626022 @default.
- W2422906106 cites W2028071281 @default.
- W2422906106 cites W2033587232 @default.
- W2422906106 cites W2042161399 @default.
- W2422906106 cites W2042282514 @default.
- W2422906106 cites W2045074061 @default.
- W2422906106 cites W2065707820 @default.
- W2422906106 cites W2065899361 @default.
- W2422906106 cites W2068568601 @default.
- W2422906106 cites W2076524169 @default.
- W2422906106 cites W2078602147 @default.
- W2422906106 cites W2082257204 @default.
- W2422906106 cites W2088409233 @default.
- W2422906106 cites W2089596288 @default.
- W2422906106 cites W2092219240 @default.
- W2422906106 cites W2095152635 @default.
- W2422906106 cites W2096576371 @default.
- W2422906106 cites W2097333015 @default.
- W2422906106 cites W2104224178 @default.
- W2422906106 cites W2108187293 @default.
- W2422906106 cites W2111031899 @default.
- W2422906106 cites W2113576333 @default.
- W2422906106 cites W2117923938 @default.
- W2422906106 cites W2119283349 @default.
- W2422906106 cites W2132604474 @default.
- W2422906106 cites W2132946599 @default.
- W2422906106 cites W2133461377 @default.
- W2422906106 cites W2136351174 @default.
- W2422906106 cites W2145265944 @default.
- W2422906106 cites W2151270203 @default.
- W2422906106 cites W2162596326 @default.
- W2422906106 cites W2170778510 @default.
- W2422906106 cites W2295822330 @default.
- W2422906106 cites W2331340643 @default.
- W2422906106 cites W4255789158 @default.
- W2422906106 doi "https://doi.org/10.1021/pr200840b" @default.
- W2422906106 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22141365" @default.
- W2422906106 hasPublicationYear "2011" @default.
- W2422906106 type Work @default.
- W2422906106 sameAs 2422906106 @default.
- W2422906106 citedByCount "61" @default.
- W2422906106 countsByYear W24229061062013 @default.
- W2422906106 countsByYear W24229061062014 @default.
- W2422906106 countsByYear W24229061062015 @default.
- W2422906106 countsByYear W24229061062016 @default.
- W2422906106 countsByYear W24229061062017 @default.
- W2422906106 countsByYear W24229061062018 @default.
- W2422906106 countsByYear W24229061062019 @default.
- W2422906106 countsByYear W24229061062020 @default.
- W2422906106 countsByYear W24229061062021 @default.
- W2422906106 countsByYear W24229061062022 @default.
- W2422906106 countsByYear W24229061062023 @default.
- W2422906106 crossrefType "journal-article" @default.
- W2422906106 hasAuthorship W2422906106A5002421690 @default.
- W2422906106 hasAuthorship W2422906106A5004310617 @default.
- W2422906106 hasAuthorship W2422906106A5026909946 @default.
- W2422906106 hasAuthorship W2422906106A5026935265 @default.
- W2422906106 hasAuthorship W2422906106A5037483221 @default.
- W2422906106 hasConcept C107872376 @default.
- W2422906106 hasConcept C112570922 @default.
- W2422906106 hasConcept C115346097 @default.
- W2422906106 hasConcept C115448650 @default.
- W2422906106 hasConcept C178790620 @default.
- W2422906106 hasConcept C181199279 @default.
- W2422906106 hasConcept C185592680 @default.
- W2422906106 hasConcept C18903297 @default.
- W2422906106 hasConcept C21565614 @default.
- W2422906106 hasConcept C2777477808 @default.
- W2422906106 hasConcept C2780155452 @default.