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- W2422955178 abstract "Several dietary supplements are actively being tested for their dual role of alleviating the metabolic perturbations and restricting the consequent cognitive dysfunctions seen in neurodegenerative disorders such as Alzheimer's disease (AD). The aim of the current study was to assess the influence of aqueous extract of cinnamon (CE) on the monosodium glutamate-induced non-transgenic rat model of AD (NTAD) established with insulin resistance, hyperglycaemia, neuronal loss, and cognitive impairment at a very early stage of life.The experimental design included oral administration of CE (50 mg/kg body weight) for 20 weeks to 2-month and 10-month-old NTAD rats. Following the treatments, the animals attained 7 and 15 months of age, respectively. They were then subjected to behavioural testing, biochemical analysis, and stereology experiments.The results demonstrated that CE treatment improved the insulin sensitivity, increased phosphorylated glycogen synthase kinase-3β (pGSK3β), inhibited the cholinesterase activity, and improved the learning ability in NTAD rats. Histological evaluation has shown an increase in neuron count in the DG sub-field of hippocampus upon treatment with CE.These beneficial effects of CE are suggestive of considering cinnamon as a dietary supplement in modulating the metabolic changes and cognitive functions." @default.
- W2422955178 created "2016-06-24" @default.
- W2422955178 creator A5053963240 @default.
- W2422955178 creator A5064379816 @default.
- W2422955178 date "2016-06-16" @default.
- W2422955178 modified "2023-10-03" @default.
- W2422955178 title "Cognition enhancing effect of the aqueous extract of<i>Cinnamomum zeylanicum</i>on non-transgenic Alzheimer's disease rat model: Biochemical, histological, and behavioural studies" @default.
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- W2422955178 doi "https://doi.org/10.1080/1028415x.2016.1194593" @default.
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