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- W2423040978 abstract "The signaling pathways which transfer information into the cell form a tissue-specific network. Protein kinase C (PKC) belongs to the inositol 1, 4, 5 trisphosphate/diacylglycerol (IP3/DG) pathway and plays a key role in cell regulation. The enzyme controls cell growth and functions through a set of negative and positive regulatory mechanisms. Some tumor promoters such as phorbol esters activate PKC by acting at the DG binding site. Others do not compete with DG and either activate PKC in the absence of phospholipids, such as arachidonic acid and bile salts, or require the presence of phospholipids, for instance a number of organic solvents. However, some promoters do not directly activate the enzyme although some of them appear to act elsewhere in the IP3/DG signaling pathway. The possibility that tumor promoters impair the expression of PKC is discussed." @default.
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- W2423040978 date "1990-01-01" @default.
- W2423040978 modified "2023-09-23" @default.
- W2423040978 title "[Role of protein kinase C in cell regulation and tumor promotion]." @default.
- W2423040978 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2400822" @default.
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