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- W2423174014 abstract "The contribution of the kininogens and cystatin C to the functional inhibitory capacity for cysteine proteinases of blood plasma and inflammatory secretions was estimated from ex vivo experiments. 98.5% of the inhibitory capacity of blood plasma for cathepsin L (4-5 microM) is provided by the kininogens ensuring a complete control of this enzyme even at a lowered kininogen concentration. Control of cathepsin B activity by the kininogens is incomplete and depends critically on the active concentration of cystatin C (70 nM in normal plasma), which is reduced in blood plasma of polytraumatized and septic patients and very low in epithelial lining fluid of the shock lung." @default.
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- W2423174014 date "1992-01-01" @default.
- W2423174014 modified "2023-09-23" @default.
- W2423174014 title "The Role of the Kininogens as Cysteine Proteinase Inhibitors in Local and Systemic Inflammation" @default.
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- W2423174014 doi "https://doi.org/10.1007/978-3-0348-7321-5_40" @default.
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