Matches in SemOpenAlex for { <https://semopenalex.org/work/W2423955690> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2423955690 endingPage "C269" @default.
- W2423955690 startingPage "C262" @default.
- W2423955690 abstract "The content of putrescine and of the polyamines (spermidine and spermine) and the activities of their biosynthetic enzymes were measured in 3T3 mouse fibroblasts and SV40-transformed mouse fibroblasts over the entire period from subculturing in fresh medium until confluence. The transformed cells had a substantially higher content of putrescine and spermidine than the 3T3 cells and higher activities of all of the biosynthetic enzymes. However, the ratio of spermine synthase to spermidine synthase was higher in the 3T3 cells, which correlated with their higher spermine-to-spermidine ratio. All of the biosynthetic enzymes increased in activity during cell growth. Ornithine decarboxylase increased 20-fold with a maximum at 24-36 h after culturing whereas S-adenosylmethionine decarboxylase increased 3-fold at the same time. Spermidine synthase increased 10- to 16-fold during the growth period whereas spermine synthase increased 2- to 3-fold. The relative enzyme activities and the changes in total polyamine content suggested that 1) the activity of S-adenosylmethionine decarboxylase limited the production of the polyamines and 2) the relative amounts of spermidine and spermine synthase determined the predominant polyamine that the available decarboxylated S-adenosylmethionine is used to synthesize. When 3T3 cells become quiescent at confluence, there was a substantial fall in the intracellular spermidine level because of a greatly increased excretion of spermidine into the medium. Spermine content also fell because there was an increased conversion of spermine into spermidine, which was then excreted. The specific excretion of spermidine did not occur with the transformed SV-3T3 cells." @default.
- W2423955690 created "2016-06-24" @default.
- W2423955690 creator A5004863246 @default.
- W2423955690 creator A5040141654 @default.
- W2423955690 creator A5071556411 @default.
- W2423955690 date "1982-11-01" @default.
- W2423955690 modified "2023-09-24" @default.
- W2423955690 title "Regulation of polyamine content in cultured fibroblasts" @default.
- W2423955690 cites W155569352 @default.
- W2423955690 cites W1570003935 @default.
- W2423955690 cites W1571660695 @default.
- W2423955690 cites W1755026595 @default.
- W2423955690 cites W1965768067 @default.
- W2423955690 cites W1971744695 @default.
- W2423955690 cites W1977042415 @default.
- W2423955690 cites W2017764106 @default.
- W2423955690 cites W2023526793 @default.
- W2423955690 cites W2037089642 @default.
- W2423955690 cites W2062373015 @default.
- W2423955690 cites W2091105071 @default.
- W2423955690 cites W2281119419 @default.
- W2423955690 cites W2337180764 @default.
- W2423955690 cites W2340445066 @default.
- W2423955690 cites W2344216779 @default.
- W2423955690 cites W237686981 @default.
- W2423955690 cites W2417234843 @default.
- W2423955690 cites W2419226843 @default.
- W2423955690 cites W4293247451 @default.
- W2423955690 doi "https://doi.org/10.1152/ajpcell.1982.243.5.c262" @default.
- W2423955690 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6291400" @default.
- W2423955690 hasPublicationYear "1982" @default.
- W2423955690 type Work @default.
- W2423955690 sameAs 2423955690 @default.
- W2423955690 citedByCount "12" @default.
- W2423955690 crossrefType "journal-article" @default.
- W2423955690 hasAuthorship W2423955690A5004863246 @default.
- W2423955690 hasAuthorship W2423955690A5040141654 @default.
- W2423955690 hasAuthorship W2423955690A5071556411 @default.
- W2423955690 hasConcept C121289238 @default.
- W2423955690 hasConcept C181199279 @default.
- W2423955690 hasConcept C185592680 @default.
- W2423955690 hasConcept C2776109719 @default.
- W2423955690 hasConcept C2777167505 @default.
- W2423955690 hasConcept C2777497464 @default.
- W2423955690 hasConcept C2780115381 @default.
- W2423955690 hasConcept C55493867 @default.
- W2423955690 hasConcept C86803240 @default.
- W2423955690 hasConceptScore W2423955690C121289238 @default.
- W2423955690 hasConceptScore W2423955690C181199279 @default.
- W2423955690 hasConceptScore W2423955690C185592680 @default.
- W2423955690 hasConceptScore W2423955690C2776109719 @default.
- W2423955690 hasConceptScore W2423955690C2777167505 @default.
- W2423955690 hasConceptScore W2423955690C2777497464 @default.
- W2423955690 hasConceptScore W2423955690C2780115381 @default.
- W2423955690 hasConceptScore W2423955690C55493867 @default.
- W2423955690 hasConceptScore W2423955690C86803240 @default.
- W2423955690 hasIssue "5" @default.
- W2423955690 hasLocation W24239556901 @default.
- W2423955690 hasLocation W24239556902 @default.
- W2423955690 hasOpenAccess W2423955690 @default.
- W2423955690 hasPrimaryLocation W24239556901 @default.
- W2423955690 hasRelatedWork W1949110994 @default.
- W2423955690 hasRelatedWork W1968714063 @default.
- W2423955690 hasRelatedWork W2030952248 @default.
- W2423955690 hasRelatedWork W2034854973 @default.
- W2423955690 hasRelatedWork W2083729530 @default.
- W2423955690 hasRelatedWork W2345067921 @default.
- W2423955690 hasRelatedWork W2414326766 @default.
- W2423955690 hasRelatedWork W3112532739 @default.
- W2423955690 hasRelatedWork W325004197 @default.
- W2423955690 hasRelatedWork W2411732706 @default.
- W2423955690 hasVolume "243" @default.
- W2423955690 isParatext "false" @default.
- W2423955690 isRetracted "false" @default.
- W2423955690 magId "2423955690" @default.
- W2423955690 workType "article" @default.