Matches in SemOpenAlex for { <https://semopenalex.org/work/W2424236546> ?p ?o ?g. }
- W2424236546 endingPage "989" @default.
- W2424236546 startingPage "980" @default.
- W2424236546 abstract "Mutations resulting in reduced signaling of the growth hormone/insulin-like growth factor-1 (GH/IGF-1) axis are associated with increased life- and healthspan across model organisms. Similar findings have been noted in human cohorts with functional mutations in the somatotropic axis, suggesting that this pathway may also be relevant to human aging and protection from age-related diseases. While epidemiological data indicate that low circulating IGF-1 level may protect aging populations from cancer, results remain inconclusive regarding most other diseases. We propose that studies in humans and animals need to consider differences in sex, pathway function, organs, and time-specific effects of GH/IGF-1 signaling in order to better define the role of the somatotropic axis in aging. Agents that modulate signaling of the GH/IGF-1 pathway are available for human use, but before they can be implemented in clinical studies that target aging and age-related diseases, researchers need to address the challenges discussed in this Review." @default.
- W2424236546 created "2016-06-24" @default.
- W2424236546 creator A5055979731 @default.
- W2424236546 creator A5075346656 @default.
- W2424236546 creator A5080433621 @default.
- W2424236546 date "2016-06-01" @default.
- W2424236546 modified "2023-10-11" @default.
- W2424236546 title "The Somatotropic Axis in Human Aging: Framework for the Current State of Knowledge and Future Research" @default.
- W2424236546 cites W132288395 @default.
- W2424236546 cites W1494983824 @default.
- W2424236546 cites W1535351994 @default.
- W2424236546 cites W1555070199 @default.
- W2424236546 cites W1644011132 @default.
- W2424236546 cites W1660936369 @default.
- W2424236546 cites W1682202565 @default.
- W2424236546 cites W1785188086 @default.
- W2424236546 cites W1875199757 @default.
- W2424236546 cites W1877654896 @default.
- W2424236546 cites W1913843018 @default.
- W2424236546 cites W1924236645 @default.
- W2424236546 cites W1924955228 @default.
- W2424236546 cites W1948856067 @default.
- W2424236546 cites W1964779097 @default.
- W2424236546 cites W1976143235 @default.
- W2424236546 cites W1976250589 @default.
- W2424236546 cites W1976811955 @default.
- W2424236546 cites W1985425785 @default.
- W2424236546 cites W1985670156 @default.
- W2424236546 cites W1986423215 @default.
- W2424236546 cites W1986612912 @default.
- W2424236546 cites W1987078661 @default.
- W2424236546 cites W1987562801 @default.
- W2424236546 cites W1991210531 @default.
- W2424236546 cites W1995026946 @default.
- W2424236546 cites W1998493448 @default.
- W2424236546 cites W2000871325 @default.
- W2424236546 cites W2003659675 @default.
- W2424236546 cites W2006200480 @default.
- W2424236546 cites W2011449660 @default.
- W2424236546 cites W2016021817 @default.
- W2424236546 cites W2019582539 @default.
- W2424236546 cites W2020780182 @default.
- W2424236546 cites W2021410503 @default.
- W2424236546 cites W2022411363 @default.
- W2424236546 cites W2031373028 @default.
- W2424236546 cites W2033107351 @default.
- W2424236546 cites W2033420871 @default.
- W2424236546 cites W2042610494 @default.
- W2424236546 cites W2045305475 @default.
- W2424236546 cites W2046506722 @default.
- W2424236546 cites W2046989794 @default.
- W2424236546 cites W2047513757 @default.
- W2424236546 cites W2049287362 @default.
- W2424236546 cites W2052268077 @default.
- W2424236546 cites W2057913302 @default.
- W2424236546 cites W2066154604 @default.
- W2424236546 cites W2066519654 @default.
- W2424236546 cites W2066927324 @default.
- W2424236546 cites W2067420381 @default.
- W2424236546 cites W2067443877 @default.
- W2424236546 cites W2073636233 @default.
- W2424236546 cites W2076210716 @default.
- W2424236546 cites W2078874563 @default.
- W2424236546 cites W2081750181 @default.
- W2424236546 cites W2094905802 @default.
- W2424236546 cites W2096452837 @default.
- W2424236546 cites W2097502952 @default.
- W2424236546 cites W2097991758 @default.
- W2424236546 cites W2099541331 @default.
- W2424236546 cites W2100304249 @default.
- W2424236546 cites W2101305821 @default.
- W2424236546 cites W2101339833 @default.
- W2424236546 cites W2102207014 @default.
- W2424236546 cites W2109250201 @default.
- W2424236546 cites W2109643174 @default.
- W2424236546 cites W2111843196 @default.
- W2424236546 cites W2112277577 @default.
- W2424236546 cites W2112402430 @default.
- W2424236546 cites W2114256596 @default.
- W2424236546 cites W2115525455 @default.
- W2424236546 cites W2119146677 @default.
- W2424236546 cites W2119593044 @default.
- W2424236546 cites W2124275123 @default.
- W2424236546 cites W2124479860 @default.
- W2424236546 cites W2124685637 @default.
- W2424236546 cites W2124855460 @default.
- W2424236546 cites W2126084656 @default.
- W2424236546 cites W2126174957 @default.
- W2424236546 cites W2127984332 @default.
- W2424236546 cites W2128325220 @default.
- W2424236546 cites W2128979080 @default.
- W2424236546 cites W2130617666 @default.
- W2424236546 cites W2134441573 @default.
- W2424236546 cites W2134928142 @default.
- W2424236546 cites W2135891224 @default.
- W2424236546 cites W2137945458 @default.
- W2424236546 cites W2138812648 @default.
- W2424236546 cites W2140516934 @default.