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- W242437977 abstract "Rabies is still a serious problem in many developing country at present it is urgent to establish a rapid and practical method to detect the presence of rabies. The aim of this study is to compare the correlation of sensitivity,specificity and reproducibility of the rapid fluorescent focus inhibition test(RFFIT)and mouse neutralization test(MNT) to detect neutralizing antibodies against rabies virus from humans serum samples taken from pre-vaccinated(40 sera) and vaccinated (52 sera) individuals were assayed for rabies-neutralizing antibodies by RFFIT and MNT. It was demonstrated that the rabies antibody titers determined in vaccinated individuals by using MNT and RFFIT showed 88.5% correspondence(r=0.886) and the sensitivity and specificity of MNT were 84.9% and 100%,while those of RFFIT were 100% and 89.0%. The coefficient of variation(CV) in reproducibility to detect the neutralizing antibodies in the same samples by using RFFIT and MNT were 13.3% and 62.3% respectively. From these observations,it is clear that the RFFIT seems to be more sensitive,reproducible and accurate than MNT,and RFFIT can be used to substitute MNT for the measurement of rabies neutralizing antibodies in most cases." @default.
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- W242437977 date "2009-01-01" @default.
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- W242437977 title "Comparative study on the detection of neutralizing antibodies against rabies by means of mouse neutralization test and rapid fluorescent focus inhibition test." @default.
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