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- W2424684978 abstract "The maternal-fetal transfer of Salbutamol was studied in vitro, in dual perfusion of isolated human placental lobules. The fraction of drug transferred to the fetal side was compared to reference substances: (14C)-antipyrine and (3H)-inulin. Salbutamol transfer ( 12 %) represents about 39 % of antipyrine and five times of inulin transfer. Studies with varying Salbutamol concentrations in the maternal arterial perfusate revealed that the drug transfer to the fetal side was effected by a flow-dependant diffusion process. We conclude that the reported effects on the fetus following a maternal drug infusion are mediated by the drug transferred accross the placenta." @default.
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- W2424684978 date "1981-01-01" @default.
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- W2424684978 title "Transfer of Salbutamol in the Human Placenta in vitro" @default.
- W2424684978 doi "https://doi.org/10.1159/000457427" @default.
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