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- W2424908177 abstract "Myelin, the lipid membrane that surrounds axons, is critical for the propagation of nervous impulses and axonal maintenance. The destruction of myelin or lack of myelin formation due to disease or injury causes severe motor and cognitive disability. Regeneration of myelin is theoretically possible but rarely happens. Myelin is synthesized as the plasma membrane of the oligodendrocyte in the central nervous system. During development, myelin and oligodendrocytes are generated from oligodendrocyte progenitors through a process modulated by extrinsic growth factors signaling to cell-intrinsic proteins. Among the key extrinsic factors are the bone morphogenetic proteins (BMPs), potent inhibitors of oligodendrocyte differentiation and myelin protein expression, likely serving to regulate myelination temporally and spatially. BMPs also promote astrocyte generation. Given the inhibitory role of BMP in oligodendrogliogenesis during development, the expression of BMP during demyelinating disease or injury was investigated, as was whether BMP upregulation could serve to prevent regeneration by both direct inhibition of myelination and increases in astrogliosis. BMPs, predominantly BMP4, were increased in animal models of spinal cord injury, stroke, multiple sclerosis, and perinatal white matter injury. A number of studies inhibited BMP signaling by infusing the injury site with the BMP-specific inhibitor noggin or transplanting stem cells engineered to secrete noggin. In most cases, noggin increased the numbers of mature oligodendrocytes and decreased numbers of astrocytes. Some studies also showed functional improvement. BMP is one of several inhibitory growth factors that now appear to inhibit myelin regeneration. Common downstream mechanisms among these factors are likely to be identified." @default.
- W2424908177 created "2016-06-24" @default.
- W2424908177 creator A5006907732 @default.
- W2424908177 date "2015-01-01" @default.
- W2424908177 modified "2023-10-18" @default.
- W2424908177 title "Bone Morphogenetic Proteins" @default.
- W2424908177 cites W123675495 @default.
- W2424908177 cites W1494055834 @default.
- W2424908177 cites W1525813631 @default.
- W2424908177 cites W1530778223 @default.
- W2424908177 cites W1541212642 @default.
- W2424908177 cites W1547429671 @default.
- W2424908177 cites W1609684706 @default.
- W2424908177 cites W1894143964 @default.
- W2424908177 cites W1896545635 @default.
- W2424908177 cites W1900556344 @default.
- W2424908177 cites W1968944196 @default.
- W2424908177 cites W1969647408 @default.
- W2424908177 cites W1969765196 @default.
- W2424908177 cites W1971714587 @default.
- W2424908177 cites W1979953624 @default.
- W2424908177 cites W1985813269 @default.
- W2424908177 cites W1987830592 @default.
- W2424908177 cites W1987885030 @default.
- W2424908177 cites W1988362929 @default.
- W2424908177 cites W1990726019 @default.
- W2424908177 cites W1991592834 @default.
- W2424908177 cites W1992187118 @default.
- W2424908177 cites W1994542928 @default.
- W2424908177 cites W1998846464 @default.
- W2424908177 cites W1999032831 @default.
- W2424908177 cites W2000630772 @default.
- W2424908177 cites W2001810970 @default.
- W2424908177 cites W2004161433 @default.
- W2424908177 cites W2009828482 @default.
- W2424908177 cites W2022380830 @default.
- W2424908177 cites W2023079484 @default.
- W2424908177 cites W2025201512 @default.
- W2424908177 cites W2028442296 @default.
- W2424908177 cites W2029988426 @default.
- W2424908177 cites W2033792890 @default.
- W2424908177 cites W2034926640 @default.
- W2424908177 cites W2035098555 @default.
- W2424908177 cites W2036518710 @default.
- W2424908177 cites W2038846947 @default.
- W2424908177 cites W2039282080 @default.
- W2424908177 cites W2040160279 @default.
- W2424908177 cites W2040773128 @default.
- W2424908177 cites W2041053636 @default.
- W2424908177 cites W2043364678 @default.
- W2424908177 cites W2043375667 @default.
- W2424908177 cites W2043505498 @default.
- W2424908177 cites W2044425706 @default.
- W2424908177 cites W2044948946 @default.
- W2424908177 cites W2048486827 @default.
- W2424908177 cites W2048995627 @default.
- W2424908177 cites W2051629575 @default.
- W2424908177 cites W2054973570 @default.
- W2424908177 cites W2055486662 @default.
- W2424908177 cites W2056216741 @default.
- W2424908177 cites W2056958245 @default.
- W2424908177 cites W2057364465 @default.
- W2424908177 cites W2058119565 @default.
- W2424908177 cites W2060525739 @default.
- W2424908177 cites W2065017983 @default.
- W2424908177 cites W2067573711 @default.
- W2424908177 cites W2069479018 @default.
- W2424908177 cites W2069562157 @default.
- W2424908177 cites W2070891328 @default.
- W2424908177 cites W2071293390 @default.
- W2424908177 cites W2072068036 @default.
- W2424908177 cites W2074558188 @default.
- W2424908177 cites W2076152867 @default.
- W2424908177 cites W2077492083 @default.
- W2424908177 cites W2079881283 @default.
- W2424908177 cites W2080613430 @default.
- W2424908177 cites W2082178034 @default.
- W2424908177 cites W2084194517 @default.
- W2424908177 cites W2086408483 @default.
- W2424908177 cites W2086796606 @default.
- W2424908177 cites W2090177945 @default.
- W2424908177 cites W2091140607 @default.
- W2424908177 cites W2095040041 @default.
- W2424908177 cites W2099270578 @default.
- W2424908177 cites W2100904149 @default.
- W2424908177 cites W2103769049 @default.
- W2424908177 cites W2107540601 @default.
- W2424908177 cites W2107625098 @default.
- W2424908177 cites W2108005154 @default.
- W2424908177 cites W2109734495 @default.
- W2424908177 cites W2110938577 @default.
- W2424908177 cites W2111428020 @default.
- W2424908177 cites W2111447973 @default.
- W2424908177 cites W2111755398 @default.
- W2424908177 cites W2113672425 @default.
- W2424908177 cites W2117719082 @default.
- W2424908177 cites W2120787848 @default.
- W2424908177 cites W2122634043 @default.