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• W2425138841 abstract "No AccessJournal of Urology1 Mar 1976Advanced Renal Cell Carcinoma: Treatment with Xenogeneic Immune Ribonucleic Acid and Appropriate Surgical Resection Donald G. Skinner, Jean B. Dekernion, Paul A. Brower, Kenneth P. Ramming, and Yosef H. Pilch Donald G. SkinnerDonald G. Skinner More articles by this author , Jean B. DekernionJean B. Dekernion More articles by this author , Paul A. BrowerPaul A. Brower More articles by this author , Kenneth P. RammingKenneth P. Ramming More articles by this author , and Yosef H. PilchYosef H. Pilch More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)59158-2AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Herein we describe the first clinical treatment of renal cell carcinoma in humans with xenogeneic immune ribonucleic acid. Twelve patients with advanced renal cell carcinoma have been treated by appropriate operations to remove tumor bulk followed by specific passive immunotherapy. Xenogeneic specific immune ribonucleic acid was prepared from the spleen of normal sheep that had received 4 weekly injections of a homogenate of renal cell carcinoma. Results indicate that 1) xenogeneic specific immune ribonucleic acid can safely be given to humans without local or systemic toxicity, 2) there is a suggestion of clinical benefit, since only 2 patients have had progression of known metastases during treatment with immune ribonucleic acid and 3) xenogeneic immune ribonucleic acid can enhance the immune response to renal cell carcinoma, as demonstrated by in vitro lymphocytotoxicity tests. © 1976 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited ByMcDonald M (2018) Current Therapy for Renal Cell CarcinomaJournal of Urology, VOL. 127, NO. 2, (211-217), Online publication date: 1-Feb-1982.Morales A, Wilson J, Pater J and Loeb M (2018) Cytoreductive Surgery and Systemic Bacillus Calmette-Guerin Therapy in Metastatic Renal Cancer: A Phase II TrialJournal of Urology, VOL. 127, NO. 2, (230-235), Online publication date: 1-Feb-1982.McNichols D, Segura J and DeWeerd J (2018) Renal Cell Carcinoma: Long-Term Survival and Late RecurrenceJournal of Urology, VOL. 126, NO. 1, (17-23), Online publication date: 1-Jul-1981.Klugo R, Detmers M, Stiles R, Talley R and Cerny J (2018) Aggressive Versus Conservative Management of Stage IV Renal Cell CarcinomaJournal of Urology, VOL. 118, NO. 2, (244-246), Online publication date: 1-Aug-1977.Montie J, Bukowski R, Deodhar S, Hewlett J, Stewart B and Straffon R (2018) Immunotherapy of Disseminated Renal Cell Carcinoma with Transfer FactorJournal of Urology, VOL. 117, NO. 5, (553-556), Online publication date: 1-May-1977.Brower P, Dekernion J and Ramming K (2018) Immune Cytolysis of Human Renal Carcinoma Mediated by Xenogeneic Immune Ribonucleic AcidJournal of Urology, VOL. 115, NO. 3, (243-245), Online publication date: 1-Mar-1976. (2018) CommentJournal of Urology, VOL. 115, NO. 3, (245-245), Online publication date: 1-Mar-1976. Volume 115Issue 3March 1976Page: 246-250 Advertisement Copyright & Permissions© 1976 by The American Urological Association Education and Research, Inc.MetricsAuthor Information Donald G. Skinner More articles by this author Jean B. Dekernion More articles by this author Paul A. Brower More articles by this author Kenneth P. Ramming More articles by this author Yosef H. Pilch More articles by this author Expand All Advertisement PDF DownloadLoading ..." @default.
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• W2425138841 title "Advanced Renal Cell Carcinoma: Treatment with Xenogeneic Immune Ribonucleic Acid and Appropriate Surgical Resection" @default.
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