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• W2425146009 abstract "Disorders of hemoglobin synthesis affect the musculoskeletal system by either causing replacement of bone by hematopoietic tissue, precipitating bone and soft tissue ischemia and necrosis, or a combination of both processes. Less frequently, joints are involved by synovial ischemia, synovial deposition of iron, or microfracture of subchondral bone. Osteopenia is a significant problem in both thalassemia and sickle cell anemia and may result in vertebral and long bone fractures. Growth disturbances are frequently seen but are not often appreciated until adolescence because of improved hematologic management. The cause of the growth problems is multifactorial and may be related to hormonal deficiencies, iron overload, hypoxia, or local trauma to the growth plate secondary to significant osteopenia." @default.
• W2425146009 created "2016-06-24" @default.
• W2425146009 creator A5084960393 @default.
• W2425146009 date "1990-01-01" @default.
• W2425146009 modified "2023-09-27" @default.
• W2425146009 title "Musculoskeletal Problems in Hemoglobinopathy" @default.
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• W2425146009 doi "https://doi.org/10.1016/s0030-5898(20)31575-3" @default.
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