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- W242519322 abstract "Cytochrome P-450 2c was estimated by /sup 125/I-protein A dot-blot immunoassay, androst-4-ene-3,17-dione 16..cap alpha..-OHase activity and Western blots in hepatic microsomes from the adult male rats dosed daily with 50 mg/kg 3-MC or 80 mg/kg PB at 17h (single dose) and 72h (3 doses). The mRNA for P-450 2c was quantitated by translation of polysomes in vitro. 3-MC repressed P-450 2c mRNA by 17h (65% decrease) and at 72h (44% decrease). The isozyme was repressed slightly at 17 (17%) and markedly at 72h (54%). PB produced a smaller decrease in P-450 2c mRNA (17h, 41%; 72h, 25%) and only a slight decrease in the isozyme (17h, 8%; 72h, 14%). When P-450 2c and its 16/sub ..cap alpha../-OHase activity were measured following HCB administration (50mg/kg), they were decreased by 2 days and virtually abolished by 7 days. HCB also decreased P-450 2c mRNA 30% at 2 days and 90% at 7 days. In contrast, HCB induced P-450c mRNA maximally by 17-24h (25-fold) followed by a decrease to 48% of maximal levels by 7 days. Doses of 3 and 10 mg/kg HCB decreased P-450 2c mRNA approximately 30% by 7 days. This study shows that the mRNA for a constitutive P-450 isozymemore » is repressed by several known inducers of P-450.« less" @default.
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- W242519322 date "1986-03-01" @default.
- W242519322 modified "2023-09-26" @default.
- W242519322 title "Repression of cytochrome P-450 2c and its mRNA by 3,4,5,3',4',5'-hexachlorobiphenyl (HCB), 3-methylcholanthrene (3-MC) and phenobarbital (PB) in livers from male rats" @default.
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