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- W2425229877 abstract "A newly synthesized compound NC-1200 (oxazolidinone) has been shown to have a powerful inhibitory action on the glutamate response at the neuromuscular junction in crayfish where glutamate is thought to be an excitatory neurotransmitter. However, the pharmacological function of NC-1200 in the CNS of mammals remains unknown. We examined the glutamate blocking action of NC-1200 on various glutamate receptors of cat's vestibular neurons. The effects of NC-1200 on secondary vestibular neurons were studied by intra-venous (3-5 mg/kg) and iontophoretic application using multi-barreled electrodes filled with NMDA, kainic acid and NC-1200 in decerebrated cats. After identification of type 1 neurons, the chemicals were applied to examine their effects on neuronal activity. The results were as follows; i) Systemic application of NC-1200 suppressed type 1 responses to yaw rotation; ii) both NMDA-mediated and kainate-mediated excitations on the vestibular neurons were abolished by application of NC-1200; iii) the suppression of various glutamic receptors was dose-dependent; and iv) the kainate receptor was more strongly suppressed than the NMDA receptor by NC-1200." @default.
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- W2425229877 date "1997-01-01" @default.
- W2425229877 modified "2023-09-23" @default.
- W2425229877 title "Effects of newly developed excitatory amino acid antagonists on vestibular type I neurons in the cat." @default.
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