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- W2425247005 abstract "Objective To investigate the expression of phosphatase of regeneration liver-3 (PRL-3) protein and its relationship with tumor invasion and metastasis in human colorectal carcinoma,and elucidate prognostic value.Methods Immunohistochemistry method was applied to detect the PRL-3 expression in the primary tumor specimens and paired paratumor normal tissues from 46 colorectal carcinoma patients, the adenoma tissues from 6 patients with colorectal adenoma, all the metastastic lymph nodes from 29 cases and the metastastic liver lesions from 6 cases. The relationship between PRL-3 expression and clinicopathologic parameters was analyzed and a survival curve was achieved according to Kaplan-Meier method. Results No or weak PRL-3 protein expression was detected in normal colorectal mucosa and colorectal adenoma. In colorectal carcinoma tissues, PRL-3 expression was confirmed in 26 of 46 cases (56.5%) of primary colorectal carcinomas (with lymph node metastasis 63.0%, without lymph node metastasis 37.0%, P=0.001 ), 26 of 29 (89.7%) lymph node metastases,and 5 of 6 liver metastases.The expression of PRL-3 was assembled in the cytoplasm of carcinoma cells and more intensively on the cell membrane.Analysis of the relationship between PRL-3 expression and the clinicopathologic features showed that PRL-3 expression was closely associated with tumor stage (P=0.019),lymph node metastasis (P=0.026),but no relationship with age,sex,tumor size,degree of differentiation was founded (P＜0.05).The mean follow-up time was 41.4 months and results showed that patients with positive expression of PBL-3 had a significantly poorer prognosis than those with negative PRL-3 expression group(P=0.032).Conclusions PRL-3 protein plays a novel role in tumor progression and metastasis of colorectal carcinoma.PRL-3 can be expected tO be a potential predictive biomarker for identifying the prognosis in eoloreetal carcinoma patients.Key words: Colorectal neoplasm; Tumor metastasis; Phosphamse of regeneration liver-3; Prognosis" @default.
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- W2425247005 date "2008-09-01" @default.
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- W2425247005 title "[Expression of phosphatase of regeneration liver-3 in human colorectal carcinoma and its prognosis value]." @default.
- W2425247005 doi "https://doi.org/10.3760/cma.j.issn.1671-0274.2008.05.021" @default.
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