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- W2425268809 abstract "A study was made of the metabolism of C 13 -labeled acetate and lactate by the repetitively contracting (2/sec.), isolated, perfused dog gastrocnemius which had been poisoned by sodium fluoroacetate. When the fluoroacetate was administered at least 1/2 hour before the substrates, there followed a weakening of the contractions, a decrease in total CO 2 output, an enhanced disappearance of glycogen, an accumulation of lactic acid and a decrease in the pH of the blood. Under these conditions it was also found that the fluoroacetate greatly reduced the conversion to CO 2 of the carboxyl carbon of acetate and of the noncarboxyl carbons of lactate, but the carboxyl carbon of lactate still contributed a large fraction of the CO 2 . These isotopic results are qualitatively consistent with predictions made from current concepts of intermediary metabolism and mode of action of fluoroacetate." @default.
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- W2425268809 date "1960-05-01" @default.
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- W2425268809 title "Effect of fluoroacetate on the metabolism of isotopic acetate and lactate by the isolated perfused dog gastrocnemius" @default.
- W2425268809 doi "https://doi.org/10.1152/ajplegacy.1960.198.5.1071" @default.
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