Matches in SemOpenAlex for { <https://semopenalex.org/work/W2425339123> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W2425339123 endingPage "43" @default.
- W2425339123 startingPage "337" @default.
- W2425339123 abstract "In the present study the hypothesis of antidepressant-induced subsensitivity of presynaptic dopamine receptors was readdressed. We used the behavioral model of low dose of apomorphine-induced locomotor hypoactivity in rats. Indeed, repeated administration of imipramine and citalopram attenuated the effect of low dose of apomorphine. However, the most interesting finding of the present study was the observation that similar and even stronger attenuation of low dose of apomorphine-induced hypoactivity was obtained by the acute treatment with imipramine, citalopram and amitriptyline, followed by 14 drug free days. That means that the acute antidepressant drug treatment seems to be sufficient to trigger the changes at the level of dopamine D2 presynaptic receptors and/or signal transduction mechanisms as a function of time, regardless of whether the drug is again administered. On the other hand, such the effect of time was not observed in the experiments using D-amphetamine as a motor stimulant. Only the repeated administration of antidepressant drugs enhanced the locomotor hyperactivity induced by D-amphetamine. Acute treatment, neither 2 h nor 14 days after the last dose, changed the D-amphetamine-induced hyperactivity. Such a difference in the time-dependent effects of antidepressant drugs on the locomotor activity induced by either the low dose of apomorphine or D-amphetamine may possibly result from the different mechanisms involved in the regulation of the biosynthesis of dopamine presynaptic and postsynaptic receptors in the rat brain." @default.
- W2425339123 created "2016-06-24" @default.
- W2425339123 creator A5035122641 @default.
- W2425339123 creator A5089673359 @default.
- W2425339123 date "1998-05-05" @default.
- W2425339123 modified "2023-09-23" @default.
- W2425339123 title "Time-dependent effects of antidepressant drugs on the low dose of apomorphine-induced locomotor hypoactivity in rats." @default.
- W2425339123 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9566033" @default.
- W2425339123 hasPublicationYear "1998" @default.
- W2425339123 type Work @default.
- W2425339123 sameAs 2425339123 @default.
- W2425339123 citedByCount "2" @default.
- W2425339123 countsByYear W24253391232013 @default.
- W2425339123 crossrefType "journal-article" @default.
- W2425339123 hasAuthorship W2425339123A5035122641 @default.
- W2425339123 hasAuthorship W2425339123A5089673359 @default.
- W2425339123 hasConcept C120069818 @default.
- W2425339123 hasConcept C126322002 @default.
- W2425339123 hasConcept C137183658 @default.
- W2425339123 hasConcept C142724271 @default.
- W2425339123 hasConcept C185592680 @default.
- W2425339123 hasConcept C204787440 @default.
- W2425339123 hasConcept C2777078754 @default.
- W2425339123 hasConcept C2777193897 @default.
- W2425339123 hasConcept C2777525119 @default.
- W2425339123 hasConcept C2779145073 @default.
- W2425339123 hasConcept C2779177272 @default.
- W2425339123 hasConcept C2779424989 @default.
- W2425339123 hasConcept C2780557958 @default.
- W2425339123 hasConcept C2781161787 @default.
- W2425339123 hasConcept C513476851 @default.
- W2425339123 hasConcept C71924100 @default.
- W2425339123 hasConcept C98274493 @default.
- W2425339123 hasConceptScore W2425339123C120069818 @default.
- W2425339123 hasConceptScore W2425339123C126322002 @default.
- W2425339123 hasConceptScore W2425339123C137183658 @default.
- W2425339123 hasConceptScore W2425339123C142724271 @default.
- W2425339123 hasConceptScore W2425339123C185592680 @default.
- W2425339123 hasConceptScore W2425339123C204787440 @default.
- W2425339123 hasConceptScore W2425339123C2777078754 @default.
- W2425339123 hasConceptScore W2425339123C2777193897 @default.
- W2425339123 hasConceptScore W2425339123C2777525119 @default.
- W2425339123 hasConceptScore W2425339123C2779145073 @default.
- W2425339123 hasConceptScore W2425339123C2779177272 @default.
- W2425339123 hasConceptScore W2425339123C2779424989 @default.
- W2425339123 hasConceptScore W2425339123C2780557958 @default.
- W2425339123 hasConceptScore W2425339123C2781161787 @default.
- W2425339123 hasConceptScore W2425339123C513476851 @default.
- W2425339123 hasConceptScore W2425339123C71924100 @default.
- W2425339123 hasConceptScore W2425339123C98274493 @default.
- W2425339123 hasIssue "5" @default.
- W2425339123 hasLocation W24253391231 @default.
- W2425339123 hasOpenAccess W2425339123 @default.
- W2425339123 hasPrimaryLocation W24253391231 @default.
- W2425339123 hasRelatedWork W1993123849 @default.
- W2425339123 hasRelatedWork W2014526184 @default.
- W2425339123 hasRelatedWork W2027355567 @default.
- W2425339123 hasRelatedWork W2046998739 @default.
- W2425339123 hasRelatedWork W2062943372 @default.
- W2425339123 hasRelatedWork W2089943833 @default.
- W2425339123 hasRelatedWork W2411728943 @default.
- W2425339123 hasRelatedWork W2425339123 @default.
- W2425339123 hasRelatedWork W2425353604 @default.
- W2425339123 hasRelatedWork W2465069858 @default.
- W2425339123 hasVolume "49" @default.
- W2425339123 isParatext "false" @default.
- W2425339123 isRetracted "false" @default.
- W2425339123 magId "2425339123" @default.
- W2425339123 workType "article" @default.