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• W2425355619 endingPage "539" @default.
• W2425355619 startingPage "514" @default.
• W2425355619 abstract "Chronic stress-related psychiatric conditions such as anxiety, depression, and alcohol abuse are an enormous public health concern. The etiology of these pathologies is complex, with psychosocial stressors being among the most frequently discussed risk factors. The brain glutamatergic neurotransmitter system has often been found involved in behaviors and pathophysiologies resulting from acute stress and fear. Despite this, relatively little is known about the role of glutamatergic system components in chronic psychosocial stress, neither in rodents nor in humans. Recently, drug discovery efforts at the metabotropic receptor subtypes of the glutamatergic system (mGlu1-8 receptors) led to the identification of pharmacological tools with emerging potential in psychiatric conditions. But again, the contribution of individual mGlu subtypes to the manifestation of physiological, molecular, and behavioral consequences of chronic psychosocial stress remains still largely unaddressed. The current review will describe animal models typically used to analyze acute and particularly chronic stress conditions, including models of psychosocial stress, and there we will discuss the emerging roles for mGlu receptor subtypes. Indeed, accumulating evidence indicates relevance and potential therapeutic usefulness of mGlu2/3 ligands and mGlu5 receptor antagonists in chronic stress-related disorders. In addition, a role for further mechanisms, e.g. mGlu7-selective compounds, is beginning to emerge. These mechanisms are important to be analyzed in chronic psychosocial stress paradigms, e.g. in the chronic subordinate colony housing (CSC) model. We summarize the early results and discuss necessary future investigations, especially for mGlu5 and mGlu7 receptor blockers, which might serve to suggest improved therapeutic strategies to treat stress-related disorders. Keywords: Animal models, anxiety, chronic stress, depression, mGlu receptors, stress-related disorders." @default.
• W2425355619 created "2016-06-24" @default.
• W2425355619 creator A5012055127 @default.
• W2425355619 creator A5064219689 @default.
• W2425355619 creator A5085329358 @default.
• W2425355619 date "2016-06-01" @default.
• W2425355619 modified "2023-10-17" @default.
• W2425355619 title "The Emerging Role of Metabotropic Glutamate Receptors in the Pathophysiology of Chronic Stress-Related Disorders" @default.
• W2425355619 cites W136483523 @default.
• W2425355619 cites W142077693 @default.
• W2425355619 cites W1487123995 @default.
• W2425355619 cites W1500978890 @default.
• W2425355619 cites W1516119904 @default.
• W2425355619 cites W1519286001 @default.
• W2425355619 cites W1521612891 @default.
• W2425355619 cites W1521660172 @default.
• W2425355619 cites W1570554881 @default.
• W2425355619 cites W1600525795 @default.
• W2425355619 cites W178728202 @default.
• W2425355619 cites W1854163003 @default.
• W2425355619 cites W1894780092 @default.
• W2425355619 cites W1902931910 @default.
• W2425355619 cites W1932328925 @default.
• W2425355619 cites W1935475606 @default.
• W2425355619 cites W1948770893 @default.
• W2425355619 cites W1965624300 @default.
• W2425355619 cites W1966546950 @default.
• W2425355619 cites W1966761076 @default.
• W2425355619 cites W1966872990 @default.
• W2425355619 cites W1966918418 @default.
• W2425355619 cites W1967356386 @default.
• W2425355619 cites W1967837120 @default.
• W2425355619 cites W1968669125 @default.
• W2425355619 cites W1968798061 @default.
• W2425355619 cites W1969480394 @default.
• W2425355619 cites W1969798938 @default.
• W2425355619 cites W1970816914 @default.
• W2425355619 cites W1970840966 @default.
• W2425355619 cites W1972183007 @default.
• W2425355619 cites W1972972579 @default.
• W2425355619 cites W1973273287 @default.
• W2425355619 cites W1974720828 @default.
• W2425355619 cites W1975071017 @default.
• W2425355619 cites W1975231884 @default.
• W2425355619 cites W1975998934 @default.
• W2425355619 cites W1976564830 @default.
• W2425355619 cites W1977118330 @default.
• W2425355619 cites W1977430165 @default.
• W2425355619 cites W1977432854 @default.
• W2425355619 cites W1978157729 @default.
• W2425355619 cites W1978346344 @default.
• W2425355619 cites W1978576636 @default.
• W2425355619 cites W1978902908 @default.
• W2425355619 cites W1979420282 @default.
• W2425355619 cites W1980049394 @default.
• W2425355619 cites W1980508260 @default.
• W2425355619 cites W1980654104 @default.
• W2425355619 cites W1980686412 @default.
• W2425355619 cites W1980704135 @default.
• W2425355619 cites W1980775650 @default.
• W2425355619 cites W1981654563 @default.
• W2425355619 cites W1981763442 @default.
• W2425355619 cites W1983457793 @default.
• W2425355619 cites W1983627283 @default.
• W2425355619 cites W1983956991 @default.
• W2425355619 cites W1983961817 @default.
• W2425355619 cites W1984864623 @default.
• W2425355619 cites W1985010918 @default.
• W2425355619 cites W1985486977 @default.
• W2425355619 cites W1985791632 @default.
• W2425355619 cites W1986133340 @default.
• W2425355619 cites W1988079633 @default.
• W2425355619 cites W1988731726 @default.
• W2425355619 cites W1988912854 @default.
• W2425355619 cites W1989458523 @default.
• W2425355619 cites W1989582790 @default.
• W2425355619 cites W1990015656 @default.
• W2425355619 cites W1990206527 @default.
• W2425355619 cites W1990418876 @default.
• W2425355619 cites W1990428243 @default.
• W2425355619 cites W1990535802 @default.
• W2425355619 cites W1991891142 @default.
• W2425355619 cites W1992090445 @default.
• W2425355619 cites W1993254538 @default.
• W2425355619 cites W1993409548 @default.
• W2425355619 cites W1993754349 @default.
• W2425355619 cites W1996805443 @default.
• W2425355619 cites W1997113206 @default.
• W2425355619 cites W1999066757 @default.
• W2425355619 cites W1999502575 @default.
• W2425355619 cites W1999748084 @default.
• W2425355619 cites W2000756368 @default.
• W2425355619 cites W2001311316 @default.
• W2425355619 cites W2002090384 @default.
• W2425355619 cites W2002346584 @default.
• W2425355619 cites W2003736358 @default.
• W2425355619 cites W2003982930 @default.
• W2425355619 cites W2004118951 @default.

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