Matches in SemOpenAlex for { <https://semopenalex.org/work/W2425502429> ?p ?o ?g. }
- W2425502429 endingPage "1158" @default.
- W2425502429 startingPage "1151" @default.
- W2425502429 abstract "Abstract Because mutations in receptor tyrosine kinases may contribute to cellular transformation, studies were undertaken to examine c-kit in human leukemia. Isoforms of c-kit have been characterized in the human megakaryoblastic leukemia cell line M-07. Deletion of the four amino acids Gly-Asn-Asn-Lys in the extracellular domain represents an alternatively spliced isoform that has been shown by others, in mice, to be associated with constitutive receptor autophosphorylation (Reith et al, EMBO J 10:2451, 1991). Additional isoforms differ in the inclusion or exclusion of a serine residue in the interkinase domain, a region that contains the binding site for phosphatidylinositol 3- kinase. By RNase protection analysis, we have shown coexpression of the Gly-Asn-Asn-Lys+ and Gly-Asn-Asn-Lys- isoforms, with dominance of the Gly-Asn-Asn-Lys- transcript, in normal human bone marrow, normal melanocytes, a range of tumor cell lines, and the blasts of 23 patients with acute myeloid leukemia. Analysis of transcripts for the Ser+ and Ser- isoforms also showed coexpression in all normal and leukemic cells examined. The ratios of isoform expression for both the Gly-Asn-Asn-Lys and Ser variants were relatively constant, providing no evidence in the tumors examined that upregulation of one isoform contributes to the neoplastic process." @default.
- W2425502429 created "2016-06-24" @default.
- W2425502429 creator A5022111438 @default.
- W2425502429 creator A5040081192 @default.
- W2425502429 creator A5040593300 @default.
- W2425502429 creator A5050296200 @default.
- W2425502429 creator A5068487268 @default.
- W2425502429 creator A5086269774 @default.
- W2425502429 date "1993-08-15" @default.
- W2425502429 modified "2023-10-05" @default.
- W2425502429 title "Expression of isoforms of the human receptor tyrosine kinase c-kit in leukemic cell lines and acute myeloid leukemia" @default.
- W2425502429 cites W14599598 @default.
- W2425502429 cites W1512958442 @default.
- W2425502429 cites W1514031343 @default.
- W2425502429 cites W1540826485 @default.
- W2425502429 cites W1563224204 @default.
- W2425502429 cites W180606804 @default.
- W2425502429 cites W193851687 @default.
- W2425502429 cites W2001961027 @default.
- W2425502429 cites W2005529016 @default.
- W2425502429 cites W2018171716 @default.
- W2425502429 cites W2037695813 @default.
- W2425502429 cites W2045593483 @default.
- W2425502429 cites W2060271381 @default.
- W2425502429 cites W2063436204 @default.
- W2425502429 cites W2064934740 @default.
- W2425502429 cites W2077047827 @default.
- W2425502429 cites W2090149923 @default.
- W2425502429 cites W2112811492 @default.
- W2425502429 cites W2124417604 @default.
- W2425502429 cites W2134812217 @default.
- W2425502429 cites W2140814882 @default.
- W2425502429 cites W2140922568 @default.
- W2425502429 cites W2151900782 @default.
- W2425502429 cites W2155493652 @default.
- W2425502429 cites W2161045200 @default.
- W2425502429 cites W2163479796 @default.
- W2425502429 cites W2243180814 @default.
- W2425502429 cites W2368691364 @default.
- W2425502429 cites W2395939399 @default.
- W2425502429 cites W2404763614 @default.
- W2425502429 cites W2408972998 @default.
- W2425502429 cites W54177783 @default.
- W2425502429 cites W69990049 @default.
- W2425502429 doi "https://doi.org/10.1182/blood.v82.4.1151.1151" @default.
- W2425502429 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7688988" @default.
- W2425502429 hasPublicationYear "1993" @default.
- W2425502429 type Work @default.
- W2425502429 sameAs 2425502429 @default.
- W2425502429 citedByCount "103" @default.
- W2425502429 countsByYear W24255024292012 @default.
- W2425502429 countsByYear W24255024292013 @default.
- W2425502429 countsByYear W24255024292014 @default.
- W2425502429 countsByYear W24255024292015 @default.
- W2425502429 countsByYear W24255024292016 @default.
- W2425502429 countsByYear W24255024292017 @default.
- W2425502429 countsByYear W24255024292018 @default.
- W2425502429 countsByYear W24255024292019 @default.
- W2425502429 countsByYear W24255024292020 @default.
- W2425502429 countsByYear W24255024292021 @default.
- W2425502429 countsByYear W24255024292022 @default.
- W2425502429 crossrefType "journal-article" @default.
- W2425502429 hasAuthorship W2425502429A5022111438 @default.
- W2425502429 hasAuthorship W2425502429A5040081192 @default.
- W2425502429 hasAuthorship W2425502429A5040593300 @default.
- W2425502429 hasAuthorship W2425502429A5050296200 @default.
- W2425502429 hasAuthorship W2425502429A5068487268 @default.
- W2425502429 hasAuthorship W2425502429A5086269774 @default.
- W2425502429 hasBestOaLocation W24255024291 @default.
- W2425502429 hasConcept C101544691 @default.
- W2425502429 hasConcept C104317684 @default.
- W2425502429 hasConcept C150109051 @default.
- W2425502429 hasConcept C153911025 @default.
- W2425502429 hasConcept C170493617 @default.
- W2425502429 hasConcept C184235292 @default.
- W2425502429 hasConcept C203014093 @default.
- W2425502429 hasConcept C2778461978 @default.
- W2425502429 hasConcept C2778729363 @default.
- W2425502429 hasConcept C2779282312 @default.
- W2425502429 hasConcept C42362537 @default.
- W2425502429 hasConcept C502942594 @default.
- W2425502429 hasConcept C53345823 @default.
- W2425502429 hasConcept C54355233 @default.
- W2425502429 hasConcept C55493867 @default.
- W2425502429 hasConcept C81885089 @default.
- W2425502429 hasConcept C86803240 @default.
- W2425502429 hasConcept C97029542 @default.
- W2425502429 hasConceptScore W2425502429C101544691 @default.
- W2425502429 hasConceptScore W2425502429C104317684 @default.
- W2425502429 hasConceptScore W2425502429C150109051 @default.
- W2425502429 hasConceptScore W2425502429C153911025 @default.
- W2425502429 hasConceptScore W2425502429C170493617 @default.
- W2425502429 hasConceptScore W2425502429C184235292 @default.
- W2425502429 hasConceptScore W2425502429C203014093 @default.
- W2425502429 hasConceptScore W2425502429C2778461978 @default.
- W2425502429 hasConceptScore W2425502429C2778729363 @default.
- W2425502429 hasConceptScore W2425502429C2779282312 @default.
- W2425502429 hasConceptScore W2425502429C42362537 @default.