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• W2425508431 abstract "In the past decade, major advances have occurred in the understanding of mammalian stem cell biology, but roadblocks (including gaps in our fundamental understanding) remain in translating this knowledge to regenerative medicine. Interestingly, a close analysis of the Saccharomyces cerevisiae literature leads to an appreciation of how much yeast biology has contributed to the conceptual framework underpinning our understanding of stem cell behavior, to the point where such insights have been internalized into the realm of the known. This Opinion article focuses on one such example, the quiescent adult mammalian stem cell, and examines concepts underlying our understanding of quiescence that can be attributed to studies in yeast. We discuss the metabolic, signaling and gene regulatory events that control entry and exit into quiescence in yeast. These processes and events retain remarkable conservation and conceptual parallels in mammalian systems, and collectively suggest a regulated program beyond the cessation of cell division. We argue that studies in yeast will continue to not only reveal fundamental concepts in quiescence, but also leaven progress in regenerative medicine." @default.
• W2425508431 created "2016-06-24" @default.
• W2425508431 creator A5042746540 @default.
• W2425508431 creator A5087749699 @default.
• W2425508431 date "2015-12-15" @default.
• W2425508431 modified "2023-10-12" @default.
• W2425508431 title "Decoding the stem cell quiescence cycle – lessons from yeast for regenerative biology" @default.
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• W2425508431 doi "https://doi.org/10.1242/jcs.177758" @default.
• W2425508431 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5695657" @default.
• W2425508431 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26672015" @default.
• W2425508431 hasPublicationYear "2015" @default.
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