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- W2425676895 abstract "Murine peritoneal macrophages, human fibroblasts and human ovarian teratocarcinoma cells were treated with CDDP (10 micrograms/ml) and poly-plat (10 micrograms/ml) for 2 h and cultured for 2-96 h. After poly-plat treatment macrophages developed cytoplasmic extensions much faster and secreted higher levels of interleukin-2 (IL-2), compared to CDDP. Poly-plat treated human fibroblasts demonstrated a significant release of IL-2 (138 pg/ml), compared to CDDP (64 pg/ml) or the untreated normal cells (31 pg/ml) after 8 h. Correspondingly there was a 53% increase in cells after poly-plat treatment compared to only 37% after CDDP. However, human ovarian teratocarcinoma cells didn't show any significant increase in IL-2 levels after poly-plat treatment and there was instead a decrease of 15% in cell numbers at 8 h. Based on our studies, we propose that poly-plat is more effective in activation of the macrophages and human fibroblasts in terms of IL-2, but not so with human ovarian teratocarcinoma cells." @default.
- W2425676895 created "2016-06-24" @default.
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- W2425676895 date "2000-08-23" @default.
- W2425676895 modified "2023-09-26" @default.
- W2425676895 title "Immune system activation by CDDP and poly-plat." @default.
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